Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma

Ryota Matsubara, Shintarou Kawano, Takahiro Kiyosue, Yuichi Goto, Mitsuhiro Hirano, Teppei Jinno, Takeshi Toyoshima, ryoji kitamura, Kazunari Oobu, Seiji Nakamura

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

抄録

This study examined immunohistochemical expression of ΔNp63, a keratinocyte stem cell marker, in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) and then to elucidate usefulness of ΔNp63 as a marker for diagnosis and prognosis. One-hundred and twelve cases of OL and 81 cases of OSCC were analyzed by immunohistochemical staining for ΔNp63, Ki-67, and cytokeratin 14. These labeling indices (LIs) were calculated, and the association of these LIs with clinicopathologic characteristics in the OL and OSCC was evaluated. In the OL, these LIs increased significantly according to the severity of epithelial dysplasia (p<0.0001). ΔNp63-LI in the OL with malignant transformation was significantly higher than that in the OL without (49.3 vs. 34.2%; p<0.01). In the OSCC, the LIs increased significantly in association with the histologic grade (p<0.0001). A significant difference between the high and low ΔNp63-LI groups was found in the incidence of cervical lymph node and distant metastasis (p<0.05). The prognosis of the high ΔNp63-LI (mean value >73.8%) group is poorer than that of the low ΔNp63-LI (mean value ≤73.8%) group (p<0.05). These results suggested that increased ΔNp63 expression is involved in malignant transformation in epithelial dysplasia and poor prognosis in OSCC.

元の言語英語
ページ(範囲)1391-1399
ページ数9
ジャーナルInternational journal of oncology
39
発行部数6
DOI
出版物ステータス出版済み - 12 1 2011

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Oral Leukoplakia
Squamous Cell Carcinoma
Keratin-14
Keratinocytes
Stem Cells
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma. / Matsubara, Ryota; Kawano, Shintarou; Kiyosue, Takahiro; Goto, Yuichi; Hirano, Mitsuhiro; Jinno, Teppei; Toyoshima, Takeshi; kitamura, ryoji; Oobu, Kazunari; Nakamura, Seiji.

:: International journal of oncology, 巻 39, 番号 6, 01.12.2011, p. 1391-1399.

研究成果: ジャーナルへの寄稿記事

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title = "Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma",
abstract = "This study examined immunohistochemical expression of ΔNp63, a keratinocyte stem cell marker, in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) and then to elucidate usefulness of ΔNp63 as a marker for diagnosis and prognosis. One-hundred and twelve cases of OL and 81 cases of OSCC were analyzed by immunohistochemical staining for ΔNp63, Ki-67, and cytokeratin 14. These labeling indices (LIs) were calculated, and the association of these LIs with clinicopathologic characteristics in the OL and OSCC was evaluated. In the OL, these LIs increased significantly according to the severity of epithelial dysplasia (p<0.0001). ΔNp63-LI in the OL with malignant transformation was significantly higher than that in the OL without (49.3 vs. 34.2{\%}; p<0.01). In the OSCC, the LIs increased significantly in association with the histologic grade (p<0.0001). A significant difference between the high and low ΔNp63-LI groups was found in the incidence of cervical lymph node and distant metastasis (p<0.05). The prognosis of the high ΔNp63-LI (mean value >73.8{\%}) group is poorer than that of the low ΔNp63-LI (mean value ≤73.8{\%}) group (p<0.05). These results suggested that increased ΔNp63 expression is involved in malignant transformation in epithelial dysplasia and poor prognosis in OSCC.",
author = "Ryota Matsubara and Shintarou Kawano and Takahiro Kiyosue and Yuichi Goto and Mitsuhiro Hirano and Teppei Jinno and Takeshi Toyoshima and ryoji kitamura and Kazunari Oobu and Seiji Nakamura",
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T1 - Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma

AU - Matsubara, Ryota

AU - Kawano, Shintarou

AU - Kiyosue, Takahiro

AU - Goto, Yuichi

AU - Hirano, Mitsuhiro

AU - Jinno, Teppei

AU - Toyoshima, Takeshi

AU - kitamura, ryoji

AU - Oobu, Kazunari

AU - Nakamura, Seiji

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N2 - This study examined immunohistochemical expression of ΔNp63, a keratinocyte stem cell marker, in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) and then to elucidate usefulness of ΔNp63 as a marker for diagnosis and prognosis. One-hundred and twelve cases of OL and 81 cases of OSCC were analyzed by immunohistochemical staining for ΔNp63, Ki-67, and cytokeratin 14. These labeling indices (LIs) were calculated, and the association of these LIs with clinicopathologic characteristics in the OL and OSCC was evaluated. In the OL, these LIs increased significantly according to the severity of epithelial dysplasia (p<0.0001). ΔNp63-LI in the OL with malignant transformation was significantly higher than that in the OL without (49.3 vs. 34.2%; p<0.01). In the OSCC, the LIs increased significantly in association with the histologic grade (p<0.0001). A significant difference between the high and low ΔNp63-LI groups was found in the incidence of cervical lymph node and distant metastasis (p<0.05). The prognosis of the high ΔNp63-LI (mean value >73.8%) group is poorer than that of the low ΔNp63-LI (mean value ≤73.8%) group (p<0.05). These results suggested that increased ΔNp63 expression is involved in malignant transformation in epithelial dysplasia and poor prognosis in OSCC.

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