Increased copy number of the gene encoding SF3B4 indicates poor prognosis in hepatocellular carcinoma

Tomohiro Iguchi, Takaaki Masuda, Sho Nambara, Shinya Kidogami, Yushi Ogawa, Qingjiang Hu, Tomoko Saito, Hidenari Hirata, Shotaro Sakimura, Ryutaro Uchi, Naoki Hayashi, Shuhei Ito, Hidetoshi Eguchi, Keishi Sugimachi, Yoshihiko Maehara, Koshi Mimori

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Background/Aim: Defects in alternative splicing contribute to carcinogenesis, cancer progression and chemoresistance. The spliceosome pathway, including SF3B4, a component of spliceosomal complex is suggested to play a role in progression of hepatocellular carcinoma (HCC); however, the clinical relevance of SF3B4 in HCC remains unknown. Patients and Methods: SF3B4 expression was evaluated by real-Time reverse transcription polymerase chain reaction in 72 HCC samples and non-cancerous liver samples. The relationship between the DNA copy number and SF3B4 expression levels was investigated using TCGA datasets. Results: SF3B4 expression was significantly higher in cancerous than in non-cancerous tissues and positively correlated with SF3B4 DNA copy number. High SF3B4 expression is significantly associated with intrahepatic metastasis and poor prognosis. These results were consistent with data from the public datasets. Conclusion: Overexpression of SF3B4, that is due to DNA copy number increase, is suggested to play a role in progression of HCC.

元の言語英語
ページ(範囲)2139-2144
ページ数6
ジャーナルAnticancer research
36
発行部数5
出版物ステータス出版済み - 1 1 2016

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Gene Dosage
Hepatocellular Carcinoma
DNA
Spliceosomes
Alternative Splicing
Reverse Transcription
Carcinogenesis
Neoplasm Metastasis
Polymerase Chain Reaction
Liver
Neoplasms
Datasets

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Increased copy number of the gene encoding SF3B4 indicates poor prognosis in hepatocellular carcinoma. / Iguchi, Tomohiro; Masuda, Takaaki; Nambara, Sho; Kidogami, Shinya; Ogawa, Yushi; Hu, Qingjiang; Saito, Tomoko; Hirata, Hidenari; Sakimura, Shotaro; Uchi, Ryutaro; Hayashi, Naoki; Ito, Shuhei; Eguchi, Hidetoshi; Sugimachi, Keishi; Maehara, Yoshihiko; Mimori, Koshi.

:: Anticancer research, 巻 36, 番号 5, 01.01.2016, p. 2139-2144.

研究成果: ジャーナルへの寄稿記事

Iguchi, T, Masuda, T, Nambara, S, Kidogami, S, Ogawa, Y, Hu, Q, Saito, T, Hirata, H, Sakimura, S, Uchi, R, Hayashi, N, Ito, S, Eguchi, H, Sugimachi, K, Maehara, Y & Mimori, K 2016, 'Increased copy number of the gene encoding SF3B4 indicates poor prognosis in hepatocellular carcinoma', Anticancer research, 巻. 36, 番号 5, pp. 2139-2144.
Iguchi T, Masuda T, Nambara S, Kidogami S, Ogawa Y, Hu Q その他. Increased copy number of the gene encoding SF3B4 indicates poor prognosis in hepatocellular carcinoma. Anticancer research. 2016 1 1;36(5):2139-2144.
Iguchi, Tomohiro ; Masuda, Takaaki ; Nambara, Sho ; Kidogami, Shinya ; Ogawa, Yushi ; Hu, Qingjiang ; Saito, Tomoko ; Hirata, Hidenari ; Sakimura, Shotaro ; Uchi, Ryutaro ; Hayashi, Naoki ; Ito, Shuhei ; Eguchi, Hidetoshi ; Sugimachi, Keishi ; Maehara, Yoshihiko ; Mimori, Koshi. / Increased copy number of the gene encoding SF3B4 indicates poor prognosis in hepatocellular carcinoma. :: Anticancer research. 2016 ; 巻 36, 番号 5. pp. 2139-2144.
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abstract = "Background/Aim: Defects in alternative splicing contribute to carcinogenesis, cancer progression and chemoresistance. The spliceosome pathway, including SF3B4, a component of spliceosomal complex is suggested to play a role in progression of hepatocellular carcinoma (HCC); however, the clinical relevance of SF3B4 in HCC remains unknown. Patients and Methods: SF3B4 expression was evaluated by real-Time reverse transcription polymerase chain reaction in 72 HCC samples and non-cancerous liver samples. The relationship between the DNA copy number and SF3B4 expression levels was investigated using TCGA datasets. Results: SF3B4 expression was significantly higher in cancerous than in non-cancerous tissues and positively correlated with SF3B4 DNA copy number. High SF3B4 expression is significantly associated with intrahepatic metastasis and poor prognosis. These results were consistent with data from the public datasets. Conclusion: Overexpression of SF3B4, that is due to DNA copy number increase, is suggested to play a role in progression of HCC.",
author = "Tomohiro Iguchi and Takaaki Masuda and Sho Nambara and Shinya Kidogami and Yushi Ogawa and Qingjiang Hu and Tomoko Saito and Hidenari Hirata and Shotaro Sakimura and Ryutaro Uchi and Naoki Hayashi and Shuhei Ito and Hidetoshi Eguchi and Keishi Sugimachi and Yoshihiko Maehara and Koshi Mimori",
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T1 - Increased copy number of the gene encoding SF3B4 indicates poor prognosis in hepatocellular carcinoma

AU - Iguchi, Tomohiro

AU - Masuda, Takaaki

AU - Nambara, Sho

AU - Kidogami, Shinya

AU - Ogawa, Yushi

AU - Hu, Qingjiang

AU - Saito, Tomoko

AU - Hirata, Hidenari

AU - Sakimura, Shotaro

AU - Uchi, Ryutaro

AU - Hayashi, Naoki

AU - Ito, Shuhei

AU - Eguchi, Hidetoshi

AU - Sugimachi, Keishi

AU - Maehara, Yoshihiko

AU - Mimori, Koshi

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background/Aim: Defects in alternative splicing contribute to carcinogenesis, cancer progression and chemoresistance. The spliceosome pathway, including SF3B4, a component of spliceosomal complex is suggested to play a role in progression of hepatocellular carcinoma (HCC); however, the clinical relevance of SF3B4 in HCC remains unknown. Patients and Methods: SF3B4 expression was evaluated by real-Time reverse transcription polymerase chain reaction in 72 HCC samples and non-cancerous liver samples. The relationship between the DNA copy number and SF3B4 expression levels was investigated using TCGA datasets. Results: SF3B4 expression was significantly higher in cancerous than in non-cancerous tissues and positively correlated with SF3B4 DNA copy number. High SF3B4 expression is significantly associated with intrahepatic metastasis and poor prognosis. These results were consistent with data from the public datasets. Conclusion: Overexpression of SF3B4, that is due to DNA copy number increase, is suggested to play a role in progression of HCC.

AB - Background/Aim: Defects in alternative splicing contribute to carcinogenesis, cancer progression and chemoresistance. The spliceosome pathway, including SF3B4, a component of spliceosomal complex is suggested to play a role in progression of hepatocellular carcinoma (HCC); however, the clinical relevance of SF3B4 in HCC remains unknown. Patients and Methods: SF3B4 expression was evaluated by real-Time reverse transcription polymerase chain reaction in 72 HCC samples and non-cancerous liver samples. The relationship between the DNA copy number and SF3B4 expression levels was investigated using TCGA datasets. Results: SF3B4 expression was significantly higher in cancerous than in non-cancerous tissues and positively correlated with SF3B4 DNA copy number. High SF3B4 expression is significantly associated with intrahepatic metastasis and poor prognosis. These results were consistent with data from the public datasets. Conclusion: Overexpression of SF3B4, that is due to DNA copy number increase, is suggested to play a role in progression of HCC.

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