Increased expression of membrane TNF-α on activated peripheral CD8+ T cells in systemic lupus erythematosus

Takahiko Horiuchi, Chika Morita, Hiroshi Tsukamoto, Hiroki Mitoma, Takuya Sawabe, Shin Ichi Harashima, Yoichiro Kashiwagi, Seiichi Okamura

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抄録

Membrane TNF-α is a precursor form of soluble TNF-α and exerts pro-inflammatory functions in a cell-to-cell contact manner. We showed that membrane TNF-α is induced upon activation on the cell surface of CD4+ T cells and CD8+ T cells. In patients with systemic lupus erythematosus (SLE), the percentage of membrane TNF-α-bearing CD8+ T cells (41.5±12.3%) was significantly higher compared with those of healthy controls (26.7±3.9%) (p=0.007) or patients with rheumatoid arthritis (29.8±15.4%) (p=0.038). Membrane TNF-α-bearing CD8+ T cells from SLE patients displayed cytotoxic activity against L929 cells. It is possible that membrane TNF-α may be involved in the increased apoptosis and the generation of autoantigens in SLE.

元の言語英語
ページ(範囲)875-879
ページ数5
ジャーナルInternational journal of molecular medicine
17
発行部数5
出版物ステータス出版済み - 5 1 2006

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Systemic Lupus Erythematosus
T-Lymphocytes
Membranes
Autoantigens
Rheumatoid Arthritis
Apoptosis

All Science Journal Classification (ASJC) codes

  • Genetics

これを引用

Increased expression of membrane TNF-α on activated peripheral CD8+ T cells in systemic lupus erythematosus. / Horiuchi, Takahiko; Morita, Chika; Tsukamoto, Hiroshi; Mitoma, Hiroki; Sawabe, Takuya; Harashima, Shin Ichi; Kashiwagi, Yoichiro; Okamura, Seiichi.

:: International journal of molecular medicine, 巻 17, 番号 5, 01.05.2006, p. 875-879.

研究成果: ジャーナルへの寄稿記事

Horiuchi, T, Morita, C, Tsukamoto, H, Mitoma, H, Sawabe, T, Harashima, SI, Kashiwagi, Y & Okamura, S 2006, 'Increased expression of membrane TNF-α on activated peripheral CD8+ T cells in systemic lupus erythematosus', International journal of molecular medicine, 巻. 17, 番号 5, pp. 875-879.
Horiuchi, Takahiko ; Morita, Chika ; Tsukamoto, Hiroshi ; Mitoma, Hiroki ; Sawabe, Takuya ; Harashima, Shin Ichi ; Kashiwagi, Yoichiro ; Okamura, Seiichi. / Increased expression of membrane TNF-α on activated peripheral CD8+ T cells in systemic lupus erythematosus. :: International journal of molecular medicine. 2006 ; 巻 17, 番号 5. pp. 875-879.
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abstract = "Membrane TNF-α is a precursor form of soluble TNF-α and exerts pro-inflammatory functions in a cell-to-cell contact manner. We showed that membrane TNF-α is induced upon activation on the cell surface of CD4+ T cells and CD8+ T cells. In patients with systemic lupus erythematosus (SLE), the percentage of membrane TNF-α-bearing CD8+ T cells (41.5±12.3{\%}) was significantly higher compared with those of healthy controls (26.7±3.9{\%}) (p=0.007) or patients with rheumatoid arthritis (29.8±15.4{\%}) (p=0.038). Membrane TNF-α-bearing CD8+ T cells from SLE patients displayed cytotoxic activity against L929 cells. It is possible that membrane TNF-α may be involved in the increased apoptosis and the generation of autoantigens in SLE.",
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AU - Horiuchi, Takahiko

AU - Morita, Chika

AU - Tsukamoto, Hiroshi

AU - Mitoma, Hiroki

AU - Sawabe, Takuya

AU - Harashima, Shin Ichi

AU - Kashiwagi, Yoichiro

AU - Okamura, Seiichi

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