Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist

Mieko Nakayama, Toyoshi Inoguchi, Toshiyo Sonta, Yasutaka Maeda, Shuji Sasaki, Fumi Sawada, Hirotaka Tsubouchi, Noriyuki Sonoda, Kunihisa Kobayashi, Hideki Sumimoto, Hajime Nawata

研究成果: Contribution to journalArticle査読

92 被引用数 (Scopus)

抄録

This study was undertaken to reveal the role of NAD(P)H oxidase in increased oxidative stress in islets of Type 2 diabetes. Immunostaining analysis showed that staining intensities of NAD(P)H oxidase components, gp91phox and p22phox, significantly increased in islets of animal models of Type 2 diabetes, OLETF rats (60 weeks of age) and db/db mice (14 weeks of age), compared with age-matched controls, respectively, correlating with increased levels of oxidative stress marker, 8-hydroxy-deoxyguanosine or 4-hydroxy-2-nonenal modified protein. In db/db mice, oral administration of angiotensin II Type 1 receptor antagonist valsartan (5 mg/kg) for 4 weeks significantly attenuated the increased expression of gp91phox and p22phox together with inhibition of oxidative stress and partially restored decreased insulin contents in islets. Angiotensin II-related increased expression of NAD(P)H oxidase may play an important role in increased oxidative stress in islets of Type 2 diabetes. This mechanism may be a novel therapeutic target for preventing β-cell damage.

本文言語英語
ページ(範囲)927-933
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
332
4
DOI
出版ステータス出版済み - 7 15 2005

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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