Increased mRNA expression of a novel prostacyclin-stimulating factor in human colon cancer

Fumio Umeda, Yasuhiro Ono, Naotaka Sekiguchi, Toshihiko Hashimoto, Mitsunori Masakado, Kazuhiko Nakamura, Yoshiharu Chijiiwa, Hajime Nawata

研究成果: Contribution to journalArticle査読

16 被引用数 (Scopus)

抄録

We recently cloned a prostacyclin (PGl2)-stimulating factor (PSF), which stimulates PGl2 production by cultured vascular cells. Immunohistochemistry and Northern blot analysis demonstrated that PSF was highly expressed in colon cancer sites compared with normal colon mucosa obtained from the same patient, as well as in cultured adenocarcinoma cell lines compared with cultured normal colon mucosal cell lines. Increased levels of the PSF protein were detected in the culture media of these adenocarcinoma cells compared with levels in the culture media of normal mucosal cells. These results suggest that PSF is closely associated with carcinogenesis of colon mucosa.

本文言語英語
ページ(範囲)213-217
ページ数5
ジャーナルJournal of gastroenterology
33
2
DOI
出版ステータス出版済み - 4 1 1998

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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