Increased posterior hippocampal volumes in children with lower increase in body mass index: A 3-year longitudinal MRI study

Teruo Hashimoto, Hikaru Takeuchi, Yasuyuki Taki, Susumu Yokota, Hiroshi Hashizume, Kohei Asano, Michiko Asano, Yuko Sassa, Rui Nouchi, Ryuta Kawashima

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

People are generally lean during childhood and show more variability in body sizes and shapes later in life. Cortical development generally correlates with body growth. However, in children cortical growth may be impaired with oversized body growth. Inverse correlations between body mass index (BMI) and brain volumes suggest that lean bodies may be associated with increased cortical volume. To clarify the positive effects of a lean body on a child's cortical development, we used MRI to measure brain structures longitudinally in 107 children and adolescents aged 5-16 years. The relationships between changes in BMI and cortical volumes during 3 years of development were investigated, while controlling for age, gender and intracranial volume changes. Voxel-based morphometry analyses revealed that an increase in the volume of the right posterior medial temporal lobe - including the hippocampus and parahippocampal gyrus - was associated with lower BMI increases. No correlations were observed between higher BMI increases and cortical volumes. Our results suggest that keeping a lean body - or not getting fat - during childhood can induce an increase in regional cortical volume rather than impair growth. This is the first longitudinal study showing positive effects of a lean body on cortical development in children.

本文言語英語
ページ(範囲)153-160
ページ数8
ジャーナルDevelopmental Neuroscience
37
2
DOI
出版ステータス出版済み - 4 24 2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経学
  • 発達神経科学

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