Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ

Akitomo Miyamoto, Keiko Nakayama, Hiroyuki Imaki, Sachiko Hirose, Yi Jiang, Masaaki Abe, Tadasuke Tsukiyama, Hiroyasu Nagahama, Shigeo Ohno, Shigetsugu Hatakeyama, Keiichi I. Nakayama

研究成果: ジャーナルへの寄稿記事

329 引用 (Scopus)

抄録

Protein kinase C (PKC), which comprises 11 closely related isoforms, has been implicated in a wide variety of cellular processes, such as growth, differentiation, secretion, apoptosis and tumour development1-4. Among the PKC isotypes, PKC-δ is unique in that its overexpression results in inhibition of cell growth5-11. Here we show that mice that lack PKC-δ exhibit expansion of the B-lymphocyte population with the formation of numerous germinal centres in the absence of stimulation. The rate of proliferation in response to stimulation was greater for B cells from PKC-δ-deficient mice than for those from wild-type mice. Adoptive transfer experiments suggested that the hyperproliferation phenotype is B-cell autonomous. Production of interleukin-6 was markedly increased in B cells of PKC-δ-null mice as a result of an increase in the DNA-binding activity of NF-IL6. Furthermore, the PKC-δ-deficient mice contain circulating autoreactive antibodies and display immune-complex-type glomerulonephritis, as well as lymphocyte infiltration in many organs. These results suggest that PKC-δ has an indispensable function in negative regulation of B-cell proliferation, and is particularly important for the establishment of B-cell tolerance.

元の言語英語
ページ(範囲)865-869
ページ数5
ジャーナルNature
416
発行部数6883
DOI
出版物ステータス出版済み - 4 25 2002

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Protein Kinase C
Immunity
B-Lymphocytes
CCAAT-Enhancer-Binding Protein-beta
Germinal Center
Adoptive Transfer
Glomerulonephritis
Antigen-Antibody Complex
Interleukin-6
Protein Isoforms
Cell Proliferation
Lymphocytes
Apoptosis
Phenotype
Antibodies
DNA
Growth
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • General

これを引用

Miyamoto, A., Nakayama, K., Imaki, H., Hirose, S., Jiang, Y., Abe, M., ... Nakayama, K. I. (2002). Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ. Nature, 416(6883), 865-869. https://doi.org/10.1038/416865a

Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ. / Miyamoto, Akitomo; Nakayama, Keiko; Imaki, Hiroyuki; Hirose, Sachiko; Jiang, Yi; Abe, Masaaki; Tsukiyama, Tadasuke; Nagahama, Hiroyasu; Ohno, Shigeo; Hatakeyama, Shigetsugu; Nakayama, Keiichi I.

:: Nature, 巻 416, 番号 6883, 25.04.2002, p. 865-869.

研究成果: ジャーナルへの寄稿記事

Miyamoto, A, Nakayama, K, Imaki, H, Hirose, S, Jiang, Y, Abe, M, Tsukiyama, T, Nagahama, H, Ohno, S, Hatakeyama, S & Nakayama, KI 2002, 'Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ', Nature, 巻. 416, 番号 6883, pp. 865-869. https://doi.org/10.1038/416865a
Miyamoto A, Nakayama K, Imaki H, Hirose S, Jiang Y, Abe M その他. Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ. Nature. 2002 4 25;416(6883):865-869. https://doi.org/10.1038/416865a
Miyamoto, Akitomo ; Nakayama, Keiko ; Imaki, Hiroyuki ; Hirose, Sachiko ; Jiang, Yi ; Abe, Masaaki ; Tsukiyama, Tadasuke ; Nagahama, Hiroyasu ; Ohno, Shigeo ; Hatakeyama, Shigetsugu ; Nakayama, Keiichi I. / Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ. :: Nature. 2002 ; 巻 416, 番号 6883. pp. 865-869.
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