Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Doppler sonography

Yuko Ohta, Koji Fujii, Hisatomi Arima, Kiyoshi Matsumura, Takuya Tsuchihashi, Masanori Tokumoto, Kazuhiko Tsuruya, Hidetoshi Kanai, Masanori Iwase, Hideki Hirakata, Mitsuo Iida

研究成果: ジャーナルへの寄稿記事

99 引用 (Scopus)

抄録

Objective: The renal resistive index (RI) and pulsatility index (PI), measured using Doppler ultrasonography, reflect intrarenal vascular resistance. We evaluated the relationship between these indices and pulse wave velocity (PWV), a measure of arterial stiffness, which reflects atherosclerosis, and determined whether renal RI and PI differ depending on the underlying renal disease. Methods: A total of 245 inpatients with or without renal impairment who underwent ultrasonographic assessment of the renal artery were enrolled in the study. Patients with renal artery stenosis or severe renal failure (serum creatinine ≥ 6 mg/dl) were excluded from the study. Results: In univariate analysis, the RI and PI of the main renal arteries and the interlobar arteries were significantly correlated with PWV. Multivariate analyses showed that PWV was independently associated with the RI of the main renal arteries (P < 0.01, R2 = 0.256). Patients with a creatinine level less than 3 mg/dl were divided into a control group without renal diseases and three groups with different underlying renal diseases: diabetic nephropathy, chronic glomerulonephritis, and nephrosclerosis. The RI and PI of the main renal arteries and the interlobar arteries were significantly higher in patients with diabetic nephropathy than in the other three groups, even after adjusting for multiple variables, including creatinine clearance. Conclusion: These results suggest that the increased RI of the renal arteries is associated with the severity of systemic atherosclerosis. Furthermore, the intrarenal vascular resistance differs depending on the underlying renal disease, and appears to increase to a greater extent in diabetic nephropathy.

元の言語英語
ページ(範囲)1905-1911
ページ数7
ジャーナルJournal of hypertension
23
発行部数10
DOI
出版物ステータス出版済み - 10 2005

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Doppler Ultrasonography
Diabetic Nephropathies
Atherosclerosis
Renal Artery
Kidney
Pulse Wave Analysis
Creatinine
Vascular Resistance
Arteries
Nephrosclerosis
Vascular Stiffness
Renal Artery Obstruction
Glomerulonephritis
Renal Insufficiency
Inpatients
Multivariate Analysis
Control Groups
Serum

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

これを引用

Ohta, Y., Fujii, K., Arima, H., Matsumura, K., Tsuchihashi, T., Tokumoto, M., ... Iida, M. (2005). Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Doppler sonography. Journal of hypertension, 23(10), 1905-1911. https://doi.org/10.1097/01.hjh.0000181323.44162.01

Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Doppler sonography. / Ohta, Yuko; Fujii, Koji; Arima, Hisatomi; Matsumura, Kiyoshi; Tsuchihashi, Takuya; Tokumoto, Masanori; Tsuruya, Kazuhiko; Kanai, Hidetoshi; Iwase, Masanori; Hirakata, Hideki; Iida, Mitsuo.

:: Journal of hypertension, 巻 23, 番号 10, 10.2005, p. 1905-1911.

研究成果: ジャーナルへの寄稿記事

Ohta, Y, Fujii, K, Arima, H, Matsumura, K, Tsuchihashi, T, Tokumoto, M, Tsuruya, K, Kanai, H, Iwase, M, Hirakata, H & Iida, M 2005, 'Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Doppler sonography', Journal of hypertension, 巻. 23, 番号 10, pp. 1905-1911. https://doi.org/10.1097/01.hjh.0000181323.44162.01
Ohta, Yuko ; Fujii, Koji ; Arima, Hisatomi ; Matsumura, Kiyoshi ; Tsuchihashi, Takuya ; Tokumoto, Masanori ; Tsuruya, Kazuhiko ; Kanai, Hidetoshi ; Iwase, Masanori ; Hirakata, Hideki ; Iida, Mitsuo. / Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Doppler sonography. :: Journal of hypertension. 2005 ; 巻 23, 番号 10. pp. 1905-1911.
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abstract = "Objective: The renal resistive index (RI) and pulsatility index (PI), measured using Doppler ultrasonography, reflect intrarenal vascular resistance. We evaluated the relationship between these indices and pulse wave velocity (PWV), a measure of arterial stiffness, which reflects atherosclerosis, and determined whether renal RI and PI differ depending on the underlying renal disease. Methods: A total of 245 inpatients with or without renal impairment who underwent ultrasonographic assessment of the renal artery were enrolled in the study. Patients with renal artery stenosis or severe renal failure (serum creatinine ≥ 6 mg/dl) were excluded from the study. Results: In univariate analysis, the RI and PI of the main renal arteries and the interlobar arteries were significantly correlated with PWV. Multivariate analyses showed that PWV was independently associated with the RI of the main renal arteries (P < 0.01, R2 = 0.256). Patients with a creatinine level less than 3 mg/dl were divided into a control group without renal diseases and three groups with different underlying renal diseases: diabetic nephropathy, chronic glomerulonephritis, and nephrosclerosis. The RI and PI of the main renal arteries and the interlobar arteries were significantly higher in patients with diabetic nephropathy than in the other three groups, even after adjusting for multiple variables, including creatinine clearance. Conclusion: These results suggest that the increased RI of the renal arteries is associated with the severity of systemic atherosclerosis. Furthermore, the intrarenal vascular resistance differs depending on the underlying renal disease, and appears to increase to a greater extent in diabetic nephropathy.",
author = "Yuko Ohta and Koji Fujii and Hisatomi Arima and Kiyoshi Matsumura and Takuya Tsuchihashi and Masanori Tokumoto and Kazuhiko Tsuruya and Hidetoshi Kanai and Masanori Iwase and Hideki Hirakata and Mitsuo Iida",
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T1 - Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Doppler sonography

AU - Ohta, Yuko

AU - Fujii, Koji

AU - Arima, Hisatomi

AU - Matsumura, Kiyoshi

AU - Tsuchihashi, Takuya

AU - Tokumoto, Masanori

AU - Tsuruya, Kazuhiko

AU - Kanai, Hidetoshi

AU - Iwase, Masanori

AU - Hirakata, Hideki

AU - Iida, Mitsuo

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N2 - Objective: The renal resistive index (RI) and pulsatility index (PI), measured using Doppler ultrasonography, reflect intrarenal vascular resistance. We evaluated the relationship between these indices and pulse wave velocity (PWV), a measure of arterial stiffness, which reflects atherosclerosis, and determined whether renal RI and PI differ depending on the underlying renal disease. Methods: A total of 245 inpatients with or without renal impairment who underwent ultrasonographic assessment of the renal artery were enrolled in the study. Patients with renal artery stenosis or severe renal failure (serum creatinine ≥ 6 mg/dl) were excluded from the study. Results: In univariate analysis, the RI and PI of the main renal arteries and the interlobar arteries were significantly correlated with PWV. Multivariate analyses showed that PWV was independently associated with the RI of the main renal arteries (P < 0.01, R2 = 0.256). Patients with a creatinine level less than 3 mg/dl were divided into a control group without renal diseases and three groups with different underlying renal diseases: diabetic nephropathy, chronic glomerulonephritis, and nephrosclerosis. The RI and PI of the main renal arteries and the interlobar arteries were significantly higher in patients with diabetic nephropathy than in the other three groups, even after adjusting for multiple variables, including creatinine clearance. Conclusion: These results suggest that the increased RI of the renal arteries is associated with the severity of systemic atherosclerosis. Furthermore, the intrarenal vascular resistance differs depending on the underlying renal disease, and appears to increase to a greater extent in diabetic nephropathy.

AB - Objective: The renal resistive index (RI) and pulsatility index (PI), measured using Doppler ultrasonography, reflect intrarenal vascular resistance. We evaluated the relationship between these indices and pulse wave velocity (PWV), a measure of arterial stiffness, which reflects atherosclerosis, and determined whether renal RI and PI differ depending on the underlying renal disease. Methods: A total of 245 inpatients with or without renal impairment who underwent ultrasonographic assessment of the renal artery were enrolled in the study. Patients with renal artery stenosis or severe renal failure (serum creatinine ≥ 6 mg/dl) were excluded from the study. Results: In univariate analysis, the RI and PI of the main renal arteries and the interlobar arteries were significantly correlated with PWV. Multivariate analyses showed that PWV was independently associated with the RI of the main renal arteries (P < 0.01, R2 = 0.256). Patients with a creatinine level less than 3 mg/dl were divided into a control group without renal diseases and three groups with different underlying renal diseases: diabetic nephropathy, chronic glomerulonephritis, and nephrosclerosis. The RI and PI of the main renal arteries and the interlobar arteries were significantly higher in patients with diabetic nephropathy than in the other three groups, even after adjusting for multiple variables, including creatinine clearance. Conclusion: These results suggest that the increased RI of the renal arteries is associated with the severity of systemic atherosclerosis. Furthermore, the intrarenal vascular resistance differs depending on the underlying renal disease, and appears to increase to a greater extent in diabetic nephropathy.

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