Increased visceral adiposity with normal weight is associated with the prevalence of non-alcoholic fatty liver disease in Japanese patients with type 2 diabetes

Ryotaro Bouchi, Takato Takeuchi, Momoko Akihisa, Norihiko Ohara, Yujiro Nakano, Rie Nishitani, Masanori Murakami, Tatsuya Fukuda, Masamichi Fujita, Isao Minami, Masatomo Mihara, Takanobu Yoshimoto, Yoshihiro Ogawa

研究成果: ジャーナルへの寄稿学術誌査読

12 被引用数 (Scopus)

抄録

Aims/Introduction: To investigate the impact of increased visceral adiposity with normal weight (OB[−]VA[+]) on the prevalence of non-alcoholic fatty liver disease in patients with type 2 diabetes. Materials and Methods: This was a cross-sectional study of 140 Japanese patients with type 2 diabetes (mean age 65 ± 11 year; 44.6% women). Visceral fat area (VFA; cm2) and liver attenuation index (LAI) were assessed by abdominal computed tomography. The patients were divided into four groups by VFA and body mass index (BMI; kg/m2) as follows: BMI <25 kg/m2 and VFA <100 cm2 (OB[−]VA[−]), BMI ≥25 kg/m2 and VFA <100 cm2 (OB[+]VA[−]), BMI <25 kg/m2 and VFA ≥100 cm2 (OB[−]VA[+]), and BMI ≥25 kg/m2 and VFA ≥100 cm2 (OB[+]VA[+]). Multivariate linear regression and logistic regression analysis were carried out to determine the impact of OB(−)VA(+) on LAI. Results: In the present study, 25.0% were OB(−)VA(+) patients, where the LAI levels were lower (1.09 ± 0.22) than those in OB(−)VA(−) patients (1.23 ± 0.15), and were equivalent to those in OB(+)VA(+) patients (1.03 ± 0.26). In multivariate linear regression analysis, OB(−)VA(+) was independently associated with LAI (standardized β−0.212, P = 0.014). In multivariate logistic regression analysis, OB(−)VA(+) was a significant predictor of LAI <0.9 (odds ratio 5.88, 95% confidence interval 1.03−33.52, P = 0.046). Conclusions: The present study provides evidence that increased visceral adiposity with normal weight is a strong predictor for the prevalence of non-alcoholic fatty liver disease in Japanese patients with type 2 diabetes.

本文言語英語
ページ(範囲)607-614
ページ数8
ジャーナルJournal of Diabetes Investigation
7
4
DOI
出版ステータス出版済み - 7月 1 2016
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 内科学
  • 内分泌学、糖尿病および代謝内科学

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