TY - JOUR
T1 - Increased visceral adiposity with normal weight is associated with the prevalence of non-alcoholic fatty liver disease in Japanese patients with type 2 diabetes
AU - Bouchi, Ryotaro
AU - Takeuchi, Takato
AU - Akihisa, Momoko
AU - Ohara, Norihiko
AU - Nakano, Yujiro
AU - Nishitani, Rie
AU - Murakami, Masanori
AU - Fukuda, Tatsuya
AU - Fujita, Masamichi
AU - Minami, Isao
AU - Mihara, Masatomo
AU - Yoshimoto, Takanobu
AU - Ogawa, Yoshihiro
N1 - Publisher Copyright:
© 2015 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Aims/Introduction: To investigate the impact of increased visceral adiposity with normal weight (OB[−]VA[+]) on the prevalence of non-alcoholic fatty liver disease in patients with type 2 diabetes. Materials and Methods: This was a cross-sectional study of 140 Japanese patients with type 2 diabetes (mean age 65 ± 11 year; 44.6% women). Visceral fat area (VFA; cm2) and liver attenuation index (LAI) were assessed by abdominal computed tomography. The patients were divided into four groups by VFA and body mass index (BMI; kg/m2) as follows: BMI <25 kg/m2 and VFA <100 cm2 (OB[−]VA[−]), BMI ≥25 kg/m2 and VFA <100 cm2 (OB[+]VA[−]), BMI <25 kg/m2 and VFA ≥100 cm2 (OB[−]VA[+]), and BMI ≥25 kg/m2 and VFA ≥100 cm2 (OB[+]VA[+]). Multivariate linear regression and logistic regression analysis were carried out to determine the impact of OB(−)VA(+) on LAI. Results: In the present study, 25.0% were OB(−)VA(+) patients, where the LAI levels were lower (1.09 ± 0.22) than those in OB(−)VA(−) patients (1.23 ± 0.15), and were equivalent to those in OB(+)VA(+) patients (1.03 ± 0.26). In multivariate linear regression analysis, OB(−)VA(+) was independently associated with LAI (standardized β−0.212, P = 0.014). In multivariate logistic regression analysis, OB(−)VA(+) was a significant predictor of LAI <0.9 (odds ratio 5.88, 95% confidence interval 1.03−33.52, P = 0.046). Conclusions: The present study provides evidence that increased visceral adiposity with normal weight is a strong predictor for the prevalence of non-alcoholic fatty liver disease in Japanese patients with type 2 diabetes.
AB - Aims/Introduction: To investigate the impact of increased visceral adiposity with normal weight (OB[−]VA[+]) on the prevalence of non-alcoholic fatty liver disease in patients with type 2 diabetes. Materials and Methods: This was a cross-sectional study of 140 Japanese patients with type 2 diabetes (mean age 65 ± 11 year; 44.6% women). Visceral fat area (VFA; cm2) and liver attenuation index (LAI) were assessed by abdominal computed tomography. The patients were divided into four groups by VFA and body mass index (BMI; kg/m2) as follows: BMI <25 kg/m2 and VFA <100 cm2 (OB[−]VA[−]), BMI ≥25 kg/m2 and VFA <100 cm2 (OB[+]VA[−]), BMI <25 kg/m2 and VFA ≥100 cm2 (OB[−]VA[+]), and BMI ≥25 kg/m2 and VFA ≥100 cm2 (OB[+]VA[+]). Multivariate linear regression and logistic regression analysis were carried out to determine the impact of OB(−)VA(+) on LAI. Results: In the present study, 25.0% were OB(−)VA(+) patients, where the LAI levels were lower (1.09 ± 0.22) than those in OB(−)VA(−) patients (1.23 ± 0.15), and were equivalent to those in OB(+)VA(+) patients (1.03 ± 0.26). In multivariate linear regression analysis, OB(−)VA(+) was independently associated with LAI (standardized β−0.212, P = 0.014). In multivariate logistic regression analysis, OB(−)VA(+) was a significant predictor of LAI <0.9 (odds ratio 5.88, 95% confidence interval 1.03−33.52, P = 0.046). Conclusions: The present study provides evidence that increased visceral adiposity with normal weight is a strong predictor for the prevalence of non-alcoholic fatty liver disease in Japanese patients with type 2 diabetes.
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U2 - 10.1111/jdi.12443
DO - 10.1111/jdi.12443
M3 - Article
C2 - 27182043
AN - SCOPUS:84977526555
VL - 7
SP - 607
EP - 614
JO - Journal of Diabetes Investigation
JF - Journal of Diabetes Investigation
SN - 2040-1116
IS - 4
ER -