Indicative value of carcinoembryonic antigen (CEA) for liver recurrence following curative resection of stage II and III gastric cancer

Yoichi Ikeda, Masaki Mori, Kiyoshi Kajiyama, Tatsuro Kamakura, Yoshihiko Maehara, Yukiaki Haraguchi, Keizo Sugimachi

研究成果: ジャーナルへの寄稿学術誌査読

28 被引用数 (Scopus)

抄録

Background/Aims: We investigated the role of preoperative and serial postoperative serum CEA levels in advanced gastric cancer patients with curative operation. Materials and Methods: Preoperative and serum postoperative CEA levels were measured in 115 patients with Stage II and III gastric cancer and who underwent curative gastric resection. Results: The 5-year survival rates of patients with high preoperative CEA levels (> 5 ng/ml) were poorer than in case of Low preoperative CEA levels (< 5 ng/ml) in both stage II(P < 0.05) and stage III (P < 0.01) gastric cancer. When the site of the recurrence was diagnosed in 47 patients with less than a 5-year survival, a high level of preoperative CEA was more likely to be associated with a liver metastasis (13/18, 72.2% than with peritoneal dissemination (4/15, 26.7% (P < 0.05). In the course of serial measurements of postoperative levels of CEA, CEA increased in patients with liver metastasis, and CEA levels began to elevate 3.2 months before clinical detection, while, little change of postoperative serum CEA levels was noted in patients with peritoneal dissemination. Conclusions: We propose that the preoperative and serial postoperative assays of serum CEA level are predictive for liver metastasis in patients with stage II and III gastric cancer and treated by curative gastric resection.

本文言語英語
ページ(範囲)1281-1287
ページ数7
ジャーナルHepato-gastroenterology
43
11
出版ステータス出版済み - 11月 6 1996

!!!All Science Journal Classification (ASJC) codes

  • 肝臓学
  • 消化器病学

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