Indicative value of carcinoembryonic antigen (CEA) for liver recurrence following curative resection of stage II and III gastric cancer

Yoichi Ikeda, Masaki Mori, Kiyoshi Kajiyama, Tatsuro Kamakura, Yoshihiko Maehara, Yukiaki Haraguchi, Keizo Sugimachi

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

抄録

Background/Aims: We investigated the role of preoperative and serial postoperative serum CEA levels in advanced gastric cancer patients with curative operation. Materials and Methods: Preoperative and serum postoperative CEA levels were measured in 115 patients with Stage II and III gastric cancer and who underwent curative gastric resection. Results: The 5-year survival rates of patients with high preoperative CEA levels (> 5 ng/ml) were poorer than in case of Low preoperative CEA levels (< 5 ng/ml) in both stage II(P < 0.05) and stage III (P < 0.01) gastric cancer. When the site of the recurrence was diagnosed in 47 patients with less than a 5-year survival, a high level of preoperative CEA was more likely to be associated with a liver metastasis (13/18, 72.2% than with peritoneal dissemination (4/15, 26.7% (P < 0.05). In the course of serial measurements of postoperative levels of CEA, CEA increased in patients with liver metastasis, and CEA levels began to elevate 3.2 months before clinical detection, while, little change of postoperative serum CEA levels was noted in patients with peritoneal dissemination. Conclusions: We propose that the preoperative and serial postoperative assays of serum CEA level are predictive for liver metastasis in patients with stage II and III gastric cancer and treated by curative gastric resection.

元の言語英語
ページ(範囲)1281-1287
ページ数7
ジャーナルHepato-Gastroenterology
43
発行部数11
出版物ステータス出版済み - 11 6 1996

Fingerprint

Carcinoembryonic Antigen
Stomach Neoplasms
Recurrence
Liver
Neoplasm Metastasis
Serum
Stomach
Survival Rate
Survival

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

これを引用

Ikeda, Y., Mori, M., Kajiyama, K., Kamakura, T., Maehara, Y., Haraguchi, Y., & Sugimachi, K. (1996). Indicative value of carcinoembryonic antigen (CEA) for liver recurrence following curative resection of stage II and III gastric cancer. Hepato-Gastroenterology, 43(11), 1281-1287.

Indicative value of carcinoembryonic antigen (CEA) for liver recurrence following curative resection of stage II and III gastric cancer. / Ikeda, Yoichi; Mori, Masaki; Kajiyama, Kiyoshi; Kamakura, Tatsuro; Maehara, Yoshihiko; Haraguchi, Yukiaki; Sugimachi, Keizo.

:: Hepato-Gastroenterology, 巻 43, 番号 11, 06.11.1996, p. 1281-1287.

研究成果: ジャーナルへの寄稿記事

Ikeda, Y, Mori, M, Kajiyama, K, Kamakura, T, Maehara, Y, Haraguchi, Y & Sugimachi, K 1996, 'Indicative value of carcinoembryonic antigen (CEA) for liver recurrence following curative resection of stage II and III gastric cancer', Hepato-Gastroenterology, 巻. 43, 番号 11, pp. 1281-1287.
Ikeda, Yoichi ; Mori, Masaki ; Kajiyama, Kiyoshi ; Kamakura, Tatsuro ; Maehara, Yoshihiko ; Haraguchi, Yukiaki ; Sugimachi, Keizo. / Indicative value of carcinoembryonic antigen (CEA) for liver recurrence following curative resection of stage II and III gastric cancer. :: Hepato-Gastroenterology. 1996 ; 巻 43, 番号 11. pp. 1281-1287.
@article{5b87939ed74945838878f7f249caa6b0,
title = "Indicative value of carcinoembryonic antigen (CEA) for liver recurrence following curative resection of stage II and III gastric cancer",
abstract = "Background/Aims: We investigated the role of preoperative and serial postoperative serum CEA levels in advanced gastric cancer patients with curative operation. Materials and Methods: Preoperative and serum postoperative CEA levels were measured in 115 patients with Stage II and III gastric cancer and who underwent curative gastric resection. Results: The 5-year survival rates of patients with high preoperative CEA levels (> 5 ng/ml) were poorer than in case of Low preoperative CEA levels (< 5 ng/ml) in both stage II(P < 0.05) and stage III (P < 0.01) gastric cancer. When the site of the recurrence was diagnosed in 47 patients with less than a 5-year survival, a high level of preoperative CEA was more likely to be associated with a liver metastasis (13/18, 72.2{\%} than with peritoneal dissemination (4/15, 26.7{\%} (P < 0.05). In the course of serial measurements of postoperative levels of CEA, CEA increased in patients with liver metastasis, and CEA levels began to elevate 3.2 months before clinical detection, while, little change of postoperative serum CEA levels was noted in patients with peritoneal dissemination. Conclusions: We propose that the preoperative and serial postoperative assays of serum CEA level are predictive for liver metastasis in patients with stage II and III gastric cancer and treated by curative gastric resection.",
author = "Yoichi Ikeda and Masaki Mori and Kiyoshi Kajiyama and Tatsuro Kamakura and Yoshihiko Maehara and Yukiaki Haraguchi and Keizo Sugimachi",
year = "1996",
month = "11",
day = "6",
language = "English",
volume = "43",
pages = "1281--1287",
journal = "Acta hepato-splenologica",
issn = "0172-6390",
publisher = "H.G.E. Update Medical Publishing Ltd.",
number = "11",

}

TY - JOUR

T1 - Indicative value of carcinoembryonic antigen (CEA) for liver recurrence following curative resection of stage II and III gastric cancer

AU - Ikeda, Yoichi

AU - Mori, Masaki

AU - Kajiyama, Kiyoshi

AU - Kamakura, Tatsuro

AU - Maehara, Yoshihiko

AU - Haraguchi, Yukiaki

AU - Sugimachi, Keizo

PY - 1996/11/6

Y1 - 1996/11/6

N2 - Background/Aims: We investigated the role of preoperative and serial postoperative serum CEA levels in advanced gastric cancer patients with curative operation. Materials and Methods: Preoperative and serum postoperative CEA levels were measured in 115 patients with Stage II and III gastric cancer and who underwent curative gastric resection. Results: The 5-year survival rates of patients with high preoperative CEA levels (> 5 ng/ml) were poorer than in case of Low preoperative CEA levels (< 5 ng/ml) in both stage II(P < 0.05) and stage III (P < 0.01) gastric cancer. When the site of the recurrence was diagnosed in 47 patients with less than a 5-year survival, a high level of preoperative CEA was more likely to be associated with a liver metastasis (13/18, 72.2% than with peritoneal dissemination (4/15, 26.7% (P < 0.05). In the course of serial measurements of postoperative levels of CEA, CEA increased in patients with liver metastasis, and CEA levels began to elevate 3.2 months before clinical detection, while, little change of postoperative serum CEA levels was noted in patients with peritoneal dissemination. Conclusions: We propose that the preoperative and serial postoperative assays of serum CEA level are predictive for liver metastasis in patients with stage II and III gastric cancer and treated by curative gastric resection.

AB - Background/Aims: We investigated the role of preoperative and serial postoperative serum CEA levels in advanced gastric cancer patients with curative operation. Materials and Methods: Preoperative and serum postoperative CEA levels were measured in 115 patients with Stage II and III gastric cancer and who underwent curative gastric resection. Results: The 5-year survival rates of patients with high preoperative CEA levels (> 5 ng/ml) were poorer than in case of Low preoperative CEA levels (< 5 ng/ml) in both stage II(P < 0.05) and stage III (P < 0.01) gastric cancer. When the site of the recurrence was diagnosed in 47 patients with less than a 5-year survival, a high level of preoperative CEA was more likely to be associated with a liver metastasis (13/18, 72.2% than with peritoneal dissemination (4/15, 26.7% (P < 0.05). In the course of serial measurements of postoperative levels of CEA, CEA increased in patients with liver metastasis, and CEA levels began to elevate 3.2 months before clinical detection, while, little change of postoperative serum CEA levels was noted in patients with peritoneal dissemination. Conclusions: We propose that the preoperative and serial postoperative assays of serum CEA level are predictive for liver metastasis in patients with stage II and III gastric cancer and treated by curative gastric resection.

UR - http://www.scopus.com/inward/record.url?scp=0029861014&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029861014&partnerID=8YFLogxK

M3 - Article

C2 - 8908563

AN - SCOPUS:0029861014

VL - 43

SP - 1281

EP - 1287

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

SN - 0172-6390

IS - 11

ER -