N-type Ca2+ channel α1B-deficient mice have increased activity (ambulation, repetitive behavior, and rearing combined), suggesting contribution by the N-type Ca2+ channel, localized in the plasma membrane and essential for neurotransmitter release, on motor activity. We evaluated the effect of a 6-wk postweaning period of either individual or group housing on the activity displayed in a novel environment with or without previous habituation. Without habituation, male homozygous α1B- deficient mice showed significantly higher activity than wild-type controls, with no influence of the housing condition. When habituated, hyperactivity was seen in individually housed but not group-housed homozygous α 1B-deficient mice. The results indicate that controlling for housing condition can be important when phenotypically analyzing mutant mice.
|ジャーナル||Journal of the American Association for Laboratory Animal Science|
|出版ステータス||出版済み - 9 2006|
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