Induced Regulatory T Cells: Their Development, Stability, and Applications

Mitsuhiro Kanamori, Hiroko Nakatsukasa, Masahiro Okada, Qianjin Lu, Akihiko Yoshimura

研究成果: Contribution to journalReview article査読

163 被引用数 (Scopus)

抄録

Regulatory T (Treg) cells, as central mediators of immune suppression, play crucial roles in many facets of immune systems. The transcription factor Foxp3 has been characterized as a master regulator of Tregs, and is induced during their thymic development. Foxp3+ Tregs can also be generated from naïve T cells after stimulation in the presence of TGF-β and IL-2; the resulting cells are called induced Tregs (iTregs) when generated in vitro, or peripheral Tregs (pTregs) when generated in vivo. Compared to tTregs, iTregs have been shown to be unstable, and attempts to generate stable iTregs have been made for clinical applications. We review here the current knowledge on the development of pTregs, iTregs, and their roles and applications.

本文言語英語
ページ(範囲)803-811
ページ数9
ジャーナルTrends in Immunology
37
11
DOI
出版ステータス出版済み - 11 1 2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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