Induction of δ-Glutamyltrans-Peptidase Positive Foci in Rat Liver by Deoxycholic Acid

Hitoshi Ura, Yoshihiko Yokose, Kazuhiro Mizumoto, Akira Nakajima, Kazuhiko Yamamoto, Ayumi Denda, Yoichi Konishi

研究成果: Contribution to journalArticle査読

9 被引用数 (Scopus)

抄録

Initiating activities of the secondary bile acids, deoxycholic acid (DCA) and lithocholic acid (LCA), were examined in terms of the induction of 7-glutamyltranspeptidase(GGT)positive foci in rat liver. A rapid induction model of enzyme-altered foci was utilized. GGT positive foci were clearly induced by DCA ranging from 0.05% to 0.5% in the diet. In contrast, the induction of GGT positive foci by LCA was less pronounced and was not dosedependent. These results suggest that DCA possesses initiating activity.

本文言語英語
ページ(範囲)216-218
ページ数3
ジャーナルJapanese Journal of Cancer Research GANN
78
3
出版ステータス出版済み - 1 1 1987
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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