Initiating activities of the secondary bile acids, deoxycholic acid (DCA) and lithocholic acid (LCA), were examined in terms of the induction of 7-glutamyltranspeptidase(GGT)positive foci in rat liver. A rapid induction model of enzyme-altered foci was utilized. GGT positive foci were clearly induced by DCA ranging from 0.05% to 0.5% in the diet. In contrast, the induction of GGT positive foci by LCA was less pronounced and was not dosedependent. These results suggest that DCA possesses initiating activity.
|ジャーナル||Japanese Journal of Cancer Research GANN|
|出版ステータス||出版済み - 1 1 1987|
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