Induction of a cytosolic 54 kDa protein in rat liver that is highly homologous to selenium-binding protein

Takumi Ishida, Kenji Tasaki, Ayako Fukuda, Yuji Ishii, Kazuta Oguri

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抄録

We have previously shown that a 54 kDa protein in rat liver is highly homologous to selenium-binding protein (SeBP) or acetaminophen-binding protein (APBP) in mice and is highly inducible by treatment with 3,3',4,4',5-pentachlorobiphenyl or 3-methylcholanthrene. In this study, we examine the effect of six typical inducers, 3-methylcholanthrene (MC), isosafrole (ISO), phenobarbital (PB), dexamethasone (DEX), clofibrate (CLO), pyrazole (PYR) and butylated hydroxytoluene (BHT), on the expression level of this 54 kDa protein. Male Wistar rats were given each inducer following a predetermined schedule. Among these inducers, the 54 kDa protein was inducible by MC and BHT. The response to MC and BHT was compared with that of NAD(P)H: quinone oxidoreductase and ethoxyresorufin O-deethylase activities. The induction mechanisms and physiological role of the 54 kDa protein are discussed in the light of our results. Copyright (C) 1998 Elsevier Science B.V.

元の言語英語
ページ(範囲)249-255
ページ数7
ジャーナルEnvironmental Toxicology and Pharmacology
6
発行部数4
DOI
出版物ステータス出版済み - 12 1 1998

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Selenium-Binding Proteins
Methylcholanthrene
Liver
Butylated Hydroxytoluene
Rats
3,4,5,3',4'-pentachlorobiphenyl
Proteins
Clofibrate
Cytochrome P-450 CYP1A1
Phenobarbital
Acetaminophen
NAD
Dexamethasone
Wistar Rats
Appointments and Schedules
Carrier Proteins
Oxidoreductases

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

これを引用

Induction of a cytosolic 54 kDa protein in rat liver that is highly homologous to selenium-binding protein. / Ishida, Takumi; Tasaki, Kenji; Fukuda, Ayako; Ishii, Yuji; Oguri, Kazuta.

:: Environmental Toxicology and Pharmacology, 巻 6, 番号 4, 01.12.1998, p. 249-255.

研究成果: ジャーナルへの寄稿記事

Ishida, Takumi ; Tasaki, Kenji ; Fukuda, Ayako ; Ishii, Yuji ; Oguri, Kazuta. / Induction of a cytosolic 54 kDa protein in rat liver that is highly homologous to selenium-binding protein. :: Environmental Toxicology and Pharmacology. 1998 ; 巻 6, 番号 4. pp. 249-255.
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