Induction of apoptosis and inhibition of DNA topoisomerase-I in K-562 cells by a marine microalgal polysaccharide

Kenichi Sogawa, Takahisa Yamada, Tomoki Sumida, Hiroyuki Hamakawa, Hiroko Kuwabara, Masahiro Matsuda, Youji Muramatsu, Hiroyuki Kose, Kozo Matsumoto, Yoshiyuki Sasaki, Koichi Okutani, Kazuya Kondo, Yasumasa Monden

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

抄録

We have previously purified an extracellular polysaccharide, D-galactan sulfate associated with L(+)-lactic acid, produced from a marine microalga Dinoflagellate Gymnodinium sp. A3 (GA3). The GA3 polysaccharide, irrespective of presence or absence of lactic acid, exhibited significant cytotoxicity, which is based on an induction of apoptotic cell death, toward human myeloid leukemia K562 cells. Furthermore, we found that the GA3 polysaccharide with or without lactic acid possesses an inhibitory effect on topoisomerase-I (topo-I). The potent cytotoxic effect of GA3 polysaccharide may result from its inhibitory effect on topo-I, because the topo-I inhibition is known to trigger apoptotic cell death. (C) 2000 Elsevier Science Inc.

元の言語英語
ページ(範囲)PL227-PL231
ジャーナルLife Sciences
66
発行部数16
DOI
出版物ステータス出版済み - 3 10 2000

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Type I DNA Topoisomerase
Polysaccharides
Apoptosis
Dinoflagellida
Lactic Acid
Cell death
Cell Death
Myeloid Leukemia
K562 Cells
Cytotoxicity
Sulfates

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

これを引用

Sogawa, K., Yamada, T., Sumida, T., Hamakawa, H., Kuwabara, H., Matsuda, M., ... Monden, Y. (2000). Induction of apoptosis and inhibition of DNA topoisomerase-I in K-562 cells by a marine microalgal polysaccharide. Life Sciences, 66(16), PL227-PL231. https://doi.org/10.1016/S0024-3205(00)00473-2

Induction of apoptosis and inhibition of DNA topoisomerase-I in K-562 cells by a marine microalgal polysaccharide. / Sogawa, Kenichi; Yamada, Takahisa; Sumida, Tomoki; Hamakawa, Hiroyuki; Kuwabara, Hiroko; Matsuda, Masahiro; Muramatsu, Youji; Kose, Hiroyuki; Matsumoto, Kozo; Sasaki, Yoshiyuki; Okutani, Koichi; Kondo, Kazuya; Monden, Yasumasa.

:: Life Sciences, 巻 66, 番号 16, 10.03.2000, p. PL227-PL231.

研究成果: ジャーナルへの寄稿記事

Sogawa, K, Yamada, T, Sumida, T, Hamakawa, H, Kuwabara, H, Matsuda, M, Muramatsu, Y, Kose, H, Matsumoto, K, Sasaki, Y, Okutani, K, Kondo, K & Monden, Y 2000, 'Induction of apoptosis and inhibition of DNA topoisomerase-I in K-562 cells by a marine microalgal polysaccharide', Life Sciences, 巻. 66, 番号 16, pp. PL227-PL231. https://doi.org/10.1016/S0024-3205(00)00473-2
Sogawa, Kenichi ; Yamada, Takahisa ; Sumida, Tomoki ; Hamakawa, Hiroyuki ; Kuwabara, Hiroko ; Matsuda, Masahiro ; Muramatsu, Youji ; Kose, Hiroyuki ; Matsumoto, Kozo ; Sasaki, Yoshiyuki ; Okutani, Koichi ; Kondo, Kazuya ; Monden, Yasumasa. / Induction of apoptosis and inhibition of DNA topoisomerase-I in K-562 cells by a marine microalgal polysaccharide. :: Life Sciences. 2000 ; 巻 66, 番号 16. pp. PL227-PL231.
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T1 - Induction of apoptosis and inhibition of DNA topoisomerase-I in K-562 cells by a marine microalgal polysaccharide

AU - Sogawa, Kenichi

AU - Yamada, Takahisa

AU - Sumida, Tomoki

AU - Hamakawa, Hiroyuki

AU - Kuwabara, Hiroko

AU - Matsuda, Masahiro

AU - Muramatsu, Youji

AU - Kose, Hiroyuki

AU - Matsumoto, Kozo

AU - Sasaki, Yoshiyuki

AU - Okutani, Koichi

AU - Kondo, Kazuya

AU - Monden, Yasumasa

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