Induction of interleukin-1β and interleukin-1 receptor antagonist mRNA by chronic treatment with various psychotropics in widespread area of rat brain

Eiji Suzuki, Futoshi Shintani, Shigenobu Kanba, Masahiro Asai, Toshio Nakaki

研究成果: ジャーナルへの寄稿学術誌査読

51 被引用数 (Scopus)

抄録

We investigated whether psychotropics orally administered to rats affect levels of interleukin-1β (IL-1β) and interleukin-1 receptor antagonist (IL-1Ra) mRNA in the hypothalamus, hippocampus, frontal cortex, and brain stem, using a reverse transcription-poymerase chain reaction method. The psychotropics tested were chlorpromazine, haloperidol, imipramine, maprotiline, fluvoxamine, and diazepam. Treatment for 28 days raised the levels of both mRNAs. The increase in IL-1Ra mRNA was 6-112 times larger than that of IL-1β mRNA in most brain regions examined. These results suggest that chronic treatment with psychotropics causes greater amplifying effects on IL-1Ra mRNA than IL-1β mRNA in the brain.

本文言語英語
ページ(範囲)201-204
ページ数4
ジャーナルNeuroscience Letters
215
3
DOI
出版ステータス出版済み - 9月 13 1996
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

フィンガープリント

「Induction of interleukin-1β and interleukin-1 receptor antagonist mRNA by chronic treatment with various psychotropics in widespread area of rat brain」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル