TY - JOUR
T1 - Induction of lethal infection with indigenous Escherichia coli in mice by fluorouracil
AU - Nomoto, K.
AU - Yokokura, T.
AU - Yoshikai, Y.
AU - Mitsuyama, M.
AU - Nomoto, K.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1991
Y1 - 1991
N2 - A single administration of fluorouracil (5-FU), a well-used cancer chemotherapeutic agent, at high doses (338-800 mg/kg) to specific pathogen free mice induced a lethal infection with Escherichia coli. The infection was manifested in all the mice treated with 5-FU 7-14 days after administration of the drug, when the number of E. coli in liver reached levels ranging from 108 to 1010 colony-forming units, and the type of the infecting bacteria was limited to E. coli. The infection was accompanied with the increase in the population levels of E. coli in the intestinal tract which reached levels about 103 to 104 times as high as those of normal mice. Administration of tegafur, a less toxic derivative of 5-FU, to mice at a lethal dose of 1280 mg/kg induced infection with E. coli similar to that induced by 5-FU. Multiple administration of both streptomycin sulfate and cephalothin to mice after treatment with 5-FU protected the mice completely from the lethal infection induced by 5-FU, suggesting that the lethality of 5-FU was due to the indigenous bacterial infection.
AB - A single administration of fluorouracil (5-FU), a well-used cancer chemotherapeutic agent, at high doses (338-800 mg/kg) to specific pathogen free mice induced a lethal infection with Escherichia coli. The infection was manifested in all the mice treated with 5-FU 7-14 days after administration of the drug, when the number of E. coli in liver reached levels ranging from 108 to 1010 colony-forming units, and the type of the infecting bacteria was limited to E. coli. The infection was accompanied with the increase in the population levels of E. coli in the intestinal tract which reached levels about 103 to 104 times as high as those of normal mice. Administration of tegafur, a less toxic derivative of 5-FU, to mice at a lethal dose of 1280 mg/kg induced infection with E. coli similar to that induced by 5-FU. Multiple administration of both streptomycin sulfate and cephalothin to mice after treatment with 5-FU protected the mice completely from the lethal infection induced by 5-FU, suggesting that the lethality of 5-FU was due to the indigenous bacterial infection.
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U2 - 10.1139/m91-037
DO - 10.1139/m91-037
M3 - Article
C2 - 1829022
AN - SCOPUS:0025809219
VL - 37
SP - 244
EP - 247
JO - Canadian Journal of Microbiology
JF - Canadian Journal of Microbiology
SN - 0008-4166
IS - 3
ER -