Induction of regulatory properties in dendritic cells by Vα14 NKT cells

Satoshi Kojo, Ken Ichiro Seino, Michishige Harada, Hiroshi Watarai, Hiroshi Wakao, Tetsuro Uchida, Toshinori Nakayama, Masaru Taniguchi

研究成果: Contribution to journalArticle査読

79 被引用数 (Scopus)

抄録

Vα14 NKT cells exhibit various immune regulatory properties in vivo, but their precise mechanisms remain to be solved. In this study, we demonstrate the mechanisms of generation of regulatory dendritic cells (DCs) by stimulation of Vα14 NKT cells in vivo. After repeated injection of α-galactosylceramide (α-GalCer) into mice, splenic DCs acquired properties of regulatory DCs in IL-10-dependent fashion, such as nonmatured phenotypes and increased IL-10 but reduced IL-12 production. The unique cytokine profile in these DCs appears to be regulated by ERK1/2 and IκB NS. These DCs also showed an ability to suppress the development of experimental allergic encephalomyelitis by generating IL-10-producing regulatory CD4 T cells in vivo. These findings contribute to explaining how Vα14 NKT cells regulate the immune responses in vivo.

本文言語英語
ページ(範囲)3648-3655
ページ数8
ジャーナルJournal of Immunology
175
6
DOI
出版ステータス出版済み - 9 15 2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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