Inferring chemogenomic features from drug-target interaction networks

Yoshihiro Yamanishi

研究成果: ジャーナルへの寄稿評論記事

4 引用 (Scopus)

抄録

Drug effects are mainly caused by the interactions between drug molecules and target proteins including primary targets and off-targets. Understanding of the molecular mechanisms behind overall drug-target interactions is crucial in the drug design process. In this paper we review recently developed methods to infer chemogenomic features (the underlying associations between drug chemical substructures and protein domains) which are strongly involved in drug-target interaction networks. We show the usefulness of the methods to detect ligand chemical fragments specific for each protein domain and ligand core substructures important for a wide range of protein families. We also discuss how to use the chemogenomic features for predicting unknown drug-target interactions on a large scale.

元の言語英語
ページ(範囲)991-999
ページ数9
ジャーナルMolecular Informatics
32
発行部数11-12
DOI
出版物ステータス出版済み - 12 1 2013

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Drug Interactions
Proteins
Pharmaceutical Preparations
Ligands
Drug interactions
Drug Design
Molecules
Protein Domains

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Medicine
  • Drug Discovery
  • Computer Science Applications
  • Organic Chemistry

これを引用

Inferring chemogenomic features from drug-target interaction networks. / Yamanishi, Yoshihiro.

:: Molecular Informatics, 巻 32, 番号 11-12, 01.12.2013, p. 991-999.

研究成果: ジャーナルへの寄稿評論記事

Yamanishi, Yoshihiro. / Inferring chemogenomic features from drug-target interaction networks. :: Molecular Informatics. 2013 ; 巻 32, 番号 11-12. pp. 991-999.
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