Inflammatory and degranulation effect of yellow sand on RBL-2H3 cells in relation to chemical and biological constituents

Parida Yamada, Tamao Hatta, Mingyuan Du, Kenji Wakimizu, Junkyu Han, Taichi Maki, Hiroko Isoda

研究成果: ジャーナルへの寄稿学術誌査読

13 被引用数 (Scopus)

抄録

Recent studie pointed out that allergic diseases have increased during the Asian dust storm event (ADSE) in Japan. Daily observations and the atmospheric concentrations of yellow sand (YS) aerosol have been increasing. In this study, YS samples collected from three sites of Japan during ADSE in 2009-2010 were used. The particles were analyzed by X-ray photoelectron spectroscopy (XPS) and X-ray fluorescence-energy dispersive spectrometer (XRF-EDS). We investigate ability of YS extract on enhancing the chemical mediator release and cytokine production from rat basophilic leukemia (RBL-2H3) cells. The dust particles at Fukuoka and Tsukuba were abundant in aluminum (Al), iron (Fe), potassium (K) and titan (Ti) than those at Naha. Concentration of the trace endotoxin and Cryptomeria japonica pollen allergen (Cry j 1) were measured in YS extract. After exposure of RBL-2H3 cells to YS extract, the Β-hexosaminidase (Β-hex) release, tumor necrosis factor-alpha (TNF-α) production were enhanced in RBL-2H3 cells. This process depends on endotoxin, Cry j 1 and other allergen present in the YS extract. YS water extract also show a strong cytotoxic effect on the cells. This data suggest that low levels of endotoxin and Cry j 1 in YS may cause allergy during the ADSE.

本文言語英語
ページ(範囲)9-17
ページ数9
ジャーナルEcotoxicology and Environmental Safety
84
DOI
出版ステータス出版済み - 10月 1 2012

!!!All Science Journal Classification (ASJC) codes

  • 汚染
  • 公衆衛生学、環境および労働衛生
  • 健康、毒物学および変異誘発

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