Infliximab for reversible dementia in acute onset of neuro-Behçet's disease: A case report and cytokine analysis

Keisuke Imabayashi, Masahiro Ayano, Kazuhiko Higashioka, Kana Yokoyama, Ken Yamamoto, Koji Takayama, Hiroki Mitoma, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro

研究成果: Contribution to journalArticle査読

抄録

We describe a 49-year-old female patient with neuro-Behçet's disease (NBD) with acute onset of fever and symptoms of dementia. High-dose glucocorticoid was partially effective for cognitive impairment, and infliximab, an anti-TNF-α antibody, gradually improved the symptoms. An analysis of cytokines showed that IP-10 in the cerebrospinal fluid was higher than that in the peripheral blood, and both decreased after treatment. This is the first known case of NBD wherein the patient with acute onset of dementia responded to a treatment with infliximab. In glucocorticoid-resistant patients, it is important to consider the introduction of infliximab to prevent irreversible brain dysfunction.

本文言語英語
論文番号577631
ジャーナルJournal of Neuroimmunology
357
DOI
出版ステータス出版済み - 8 15 2021

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 神経学
  • 臨床神経学

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