Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats

Y. Yoshiyama, S. Nishikawa, T. Sugiyama, T. Kobayashi, H. Shimada, F. Tomonaga, S. Ohdo, N. Ogawa, S. Nakano

研究成果: Contribution to journalComment/debate

26 引用 (Scopus)

抜粋

Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminoglycosides.

元の言語英語
ページ(範囲)2042-2043
ページ数2
ジャーナルAntimicrobial Agents and Chemotherapy
37
発行部数9
DOI
出版物ステータス出版済み - 1993

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

フィンガープリント Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Yoshiyama, Y., Nishikawa, S., Sugiyama, T., Kobayashi, T., Shimada, H., Tomonaga, F., Ohdo, S., Ogawa, N., & Nakano, S. (1993). Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats. Antimicrobial Agents and Chemotherapy, 37(9), 2042-2043. https://doi.org/10.1128/AAC.37.9.2042