Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats

Y. Yoshiyama, S. Nishikawa, T. Sugiyama, T. Kobayashi, H. Shimada, F. Tomonaga, S. Ohdo, N. Ogawa, S. Nakano

研究成果: ジャーナルへの寄稿コメント/討論

26 引用 (Scopus)

抄録

Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminoglycosides.

元の言語英語
ページ(範囲)2042-2043
ページ数2
ジャーナルAntimicrobial Agents and Chemotherapy
37
発行部数9
DOI
出版物ステータス出版済み - 1 1 1993
外部発表Yes

Fingerprint

Appointments and Schedules
Pharmacokinetics
Aminoglycosides
Injections
Therapeutics
isepamicin

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

これを引用

Yoshiyama, Y., Nishikawa, S., Sugiyama, T., Kobayashi, T., Shimada, H., Tomonaga, F., ... Nakano, S. (1993). Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats. Antimicrobial Agents and Chemotherapy, 37(9), 2042-2043. https://doi.org/10.1128/AAC.37.9.2042

Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats. / Yoshiyama, Y.; Nishikawa, S.; Sugiyama, T.; Kobayashi, T.; Shimada, H.; Tomonaga, F.; Ohdo, S.; Ogawa, N.; Nakano, S.

:: Antimicrobial Agents and Chemotherapy, 巻 37, 番号 9, 01.01.1993, p. 2042-2043.

研究成果: ジャーナルへの寄稿コメント/討論

Yoshiyama, Y, Nishikawa, S, Sugiyama, T, Kobayashi, T, Shimada, H, Tomonaga, F, Ohdo, S, Ogawa, N & Nakano, S 1993, 'Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats', Antimicrobial Agents and Chemotherapy, 巻. 37, 番号 9, pp. 2042-2043. https://doi.org/10.1128/AAC.37.9.2042
Yoshiyama, Y. ; Nishikawa, S. ; Sugiyama, T. ; Kobayashi, T. ; Shimada, H. ; Tomonaga, F. ; Ohdo, S. ; Ogawa, N. ; Nakano, S. / Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats. :: Antimicrobial Agents and Chemotherapy. 1993 ; 巻 37, 番号 9. pp. 2042-2043.
@article{fd633c0e00244fd8b2fcb1ab18c98dff,
title = "Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats",
abstract = "Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminoglycosides.",
author = "Y. Yoshiyama and S. Nishikawa and T. Sugiyama and T. Kobayashi and H. Shimada and F. Tomonaga and S. Ohdo and N. Ogawa and S. Nakano",
year = "1993",
month = "1",
day = "1",
doi = "10.1128/AAC.37.9.2042",
language = "English",
volume = "37",
pages = "2042--2043",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "9",

}

TY - JOUR

T1 - Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats

AU - Yoshiyama, Y.

AU - Nishikawa, S.

AU - Sugiyama, T.

AU - Kobayashi, T.

AU - Shimada, H.

AU - Tomonaga, F.

AU - Ohdo, S.

AU - Ogawa, N.

AU - Nakano, S.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminoglycosides.

AB - Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminoglycosides.

UR - http://www.scopus.com/inward/record.url?scp=0027291902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027291902&partnerID=8YFLogxK

U2 - 10.1128/AAC.37.9.2042

DO - 10.1128/AAC.37.9.2042

M3 - Comment/debate

C2 - 8239630

AN - SCOPUS:0027291902

VL - 37

SP - 2042

EP - 2043

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 9

ER -