Influence of cyclic variation of right ventricular volume on left ventricular mechanical parameters measured with conductance catheter

Y. Tanoue, S. Morita, M. Hisahara, R. Tominaga, Y. Kawachi, H. Yasui

研究成果: ジャーナルへの寄稿記事

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The conductance catheter is widely used for the continuous measurement of the left ventricular (LV) pressure-volume loops. Cyclical change of the right ventricular (RV) volume may alter the parallel conductance volume, thereby affecting the LV mechanical parameters. Using 8 open-chest adult mongrel dogs, multiple LV pressure-volume loops were obtained by 2 methods: first with a vena cava occlusion (VCO) method, which involved RV volume alteration, and second with a right-heart-bypass (RHB) preparation, which decompressed the right ventricle completely. The slope of the end-systolic pressure-volume relation (Ees), the end-systolic volume associated with the end-systolic pressure of 100 mmHg (V100,es), stiffness constant (β), and the end-diastolic volume associated with the end-diastolic pressure of 9 mmHg (V9,ed) were calculated from each loop. There was minimal influence from RV volume alteration on systolic-phase indices [Ees (VCO method, 6.37±1.91 mmHg/ml; RHB preparation, 6.60±1.66 mmHg/ml; p=0.356), and V100,es (VCO method, 18.4±9.3 ml; RHB preparation, 17.8±9.0 ml; p=0.681)], but there was a significant influence on diastolic-phase indices [β (VCO method, 0.0599±0.0152; RHB preparation, 0.0839±0.0150; p=0.007), and V9,ed (VCO method, 35.6±11.3 ml; RHB preparation, 31.9±12.3 ml; p=0.001)]. The increase in the RV volume in the diastolic phase increased the parallel conductance volume, causing overestimation of the LV diastolic volume measured by the conductance catheter.

元の言語英語
ページ(範囲)749-752
ページ数4
ジャーナルJAPANESE CIRCULATION JOURNAL
65
発行部数8
DOI
出版物ステータス出版済み - 8 23 2001

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All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

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