Influence of Dai-kenchu-to (DKT) on human portal blood flow

Takashi Ogasawara, Yuji Marine, Tetsuya Ikemoto, Satoru Imura, Masahiko Fujii, Yuji Soejima, Mitsuo Shimada

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Background/Aims: Dai-kenchu-to (DKT) is known as an herbal medicine used for postoperative ileus. However, no report exists about the effect of DKT on portal blood flow. The aim of this study is to clarify the influence of DKT on portal blood flow. Methodology: To healthy volunteers (Healthy; n=6), cirrhotic patients (Cirrhosis; n=7) and liver-transplant patients (LTx; n=3), DKT (2.5g) with 100mL of warm water was orally administrated in the DKT group, and only warm water was administrated in the control group. The portal blood flow rate (M-VEL: cm/sec.) and portal blood flow (Flow volume: mL/min.) was measured each time after administration using an ultrasonic Doppler method. Furthermore, the arterial blood pressure and heart rate was measured at the same time points. Results: In the DKT group, a significant increase of M-VEL (120%) and flow volume (150%) 30 minutes after administration was observed in both Healthy and Cirrhosis in comparison with the control group. In LTx, there was also a significant increase of flow volume (128%) 30 minutes after administration. However, there was no change in average blood pressure and heart rate in all groups. Conclusions: DKT increases portal blood flow in early phase after oral administration without any significant changes in the blood pressure and heart rate.

元の言語英語
ページ(範囲)574-577
ページ数4
ジャーナルHepato-Gastroenterology
55
発行部数82-83
出版物ステータス出版済み - 3 2008
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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    Ogasawara, T., Marine, Y., Ikemoto, T., Imura, S., Fujii, M., Soejima, Y., & Shimada, M. (2008). Influence of Dai-kenchu-to (DKT) on human portal blood flow. Hepato-Gastroenterology, 55(82-83), 574-577.