Influence of dioxin-related compounds on physical function in Yusho incident victims

Jun ichi Fukushi, Hidetoshi Tsushima, Yoshihiro Matsumoto, Chikage Mitoma, Masutaka Furue, Hisaaki Miyahara, Yasuharu Nakashima

研究成果: ジャーナルへの寄稿記事

抄録

Purpose: Few studies have examined the influence of dioxin-related compounds on human physical function, and existing results are inconsistent. In 1968, accidental human exposure to rice oil contaminated with dioxin-related compounds resulted in the development of Yusho oil disease in Japan. We aimed to determine whether the degree of exposure to dioxin-related compounds was associated with physical function in Yusho patients. Methods: In 2016, 65 men (average age: 65.7 years) and 77 women (average age: 64.7 years) participated in a nationwide health examination in Fukuoka prefecture. Functional reach, gait speed, hand grip strength, and toe grip strength were evaluated as part of physical function. The serum levels of polychlorinated dibenzo-p-dioxin, polychlorinated dibenzofurans, and non-ortho polychlorinated biphenyls were measured using high-resolution gas chromatography and high-resolution mass spectrometry. We examined the association between physical function tests and serum toxic equivalency (TEQ) values. Results: A 10-fold increase in serum TEQ levels was negatively associated with functional reach (adjusted b = -4.07, p = 0.017) and hand grip strength (adjusted b = -2.20, p = 0.0245) in men. No association was observed between serum TEQ level and physical function in women. Conclusion: Our findings suggest that dioxin-related compounds have a negative influence on physical function in men. However, these findings should be interpreted carefully. Future studies examining additional data on musculoskeletal disorders are warranted.

元の言語英語
記事番号e02702
ジャーナルHeliyon
5
発行部数10
DOI
出版物ステータス出版済み - 10 2019

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Dioxins
Hand Strength
Poisons
Serum
Oils
Polychlorinated Biphenyls
antineoplaston A10
Toes
Gas Chromatography
Mass Spectrometry
Japan
Health

All Science Journal Classification (ASJC) codes

  • General

これを引用

Influence of dioxin-related compounds on physical function in Yusho incident victims. / Fukushi, Jun ichi; Tsushima, Hidetoshi; Matsumoto, Yoshihiro; Mitoma, Chikage; Furue, Masutaka; Miyahara, Hisaaki; Nakashima, Yasuharu.

:: Heliyon, 巻 5, 番号 10, e02702, 10.2019.

研究成果: ジャーナルへの寄稿記事

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AU - Mitoma, Chikage

AU - Furue, Masutaka

AU - Miyahara, Hisaaki

AU - Nakashima, Yasuharu

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N2 - Purpose: Few studies have examined the influence of dioxin-related compounds on human physical function, and existing results are inconsistent. In 1968, accidental human exposure to rice oil contaminated with dioxin-related compounds resulted in the development of Yusho oil disease in Japan. We aimed to determine whether the degree of exposure to dioxin-related compounds was associated with physical function in Yusho patients. Methods: In 2016, 65 men (average age: 65.7 years) and 77 women (average age: 64.7 years) participated in a nationwide health examination in Fukuoka prefecture. Functional reach, gait speed, hand grip strength, and toe grip strength were evaluated as part of physical function. The serum levels of polychlorinated dibenzo-p-dioxin, polychlorinated dibenzofurans, and non-ortho polychlorinated biphenyls were measured using high-resolution gas chromatography and high-resolution mass spectrometry. We examined the association between physical function tests and serum toxic equivalency (TEQ) values. Results: A 10-fold increase in serum TEQ levels was negatively associated with functional reach (adjusted b = -4.07, p = 0.017) and hand grip strength (adjusted b = -2.20, p = 0.0245) in men. No association was observed between serum TEQ level and physical function in women. Conclusion: Our findings suggest that dioxin-related compounds have a negative influence on physical function in men. However, these findings should be interpreted carefully. Future studies examining additional data on musculoskeletal disorders are warranted.

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