Influence of genetic polymorphisms and habitual caffeine intake on the changes in blood pressure, pulse rate, and calculation speed after caffeine intake

A prospective, double blind, randomized trial in healthy volunteers

Tatsuya Yoshihara, Masayoshi Zaitsu, Fumie Shiraishi, Hisatomi Arima, Fumi Takahashi-Yanaga, masaki arioka, Shunichi Kajioka, Toshiyuki Sasaguri

研究成果: ジャーナルへの寄稿記事

抄録

The aim of this study was to investigate the contribution of gene polymorphisms, in combination with habitual caffeine consumption, to the effect of caffeine intake on hemodynamic and psychoactive parameters. A double-blind, prospective study was conducted with 201 healthy volunteers randomly allocated 2:1 to the caffeinated group (150 mL decaffeinated coffee with additional 200 mg caffeine) or decaffeinated group (150 mL decaffeinated coffee). We measured the changes in blood pressure (BP) and calculation speed upon coffee intake, stratifying with gene polymorphisms, e.g., those in adenosine A 2A receptor (ADORA2A) and cytochrome P450 (CYP) 1A2, and daily caffeine consumption (≤90 mg/day and >90 mg/day). Overall, caffeine intake independently increased BP and calculation speed (p-values < 0.05), irrespective of the polymorphisms. In stratified analysis, a statistical significance within the caffeinated group was observed for the change in systolic BP in the stratum of CYP1A2 polymorphism with daily caffeine consumption ≤90 mg/day: change in systolic BP in the CYP1A2 rs762551 CC group (mean ± SD = 11.8 ± 5.9) was higher than that in the AA/CA group (4.1 ± 5.5). Gene polymorphisms may limitedly modify the effect of caffeine intake on hemodynamic parameters in combination with habitual caffeine consumption.

元の言語英語
ページ(範囲)209-214
ページ数6
ジャーナルJournal of Pharmacological Sciences
139
発行部数3
DOI
出版物ステータス出版済み - 3 1 2019

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Genetic Polymorphisms
Caffeine
Healthy Volunteers
Heart Rate
Blood Pressure
Cytochrome P-450 CYP1A2
Coffee
Hemodynamics
Adenosine A2A Receptors
Genes
Double-Blind Method
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

これを引用

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title = "Influence of genetic polymorphisms and habitual caffeine intake on the changes in blood pressure, pulse rate, and calculation speed after caffeine intake: A prospective, double blind, randomized trial in healthy volunteers",
abstract = "The aim of this study was to investigate the contribution of gene polymorphisms, in combination with habitual caffeine consumption, to the effect of caffeine intake on hemodynamic and psychoactive parameters. A double-blind, prospective study was conducted with 201 healthy volunteers randomly allocated 2:1 to the caffeinated group (150 mL decaffeinated coffee with additional 200 mg caffeine) or decaffeinated group (150 mL decaffeinated coffee). We measured the changes in blood pressure (BP) and calculation speed upon coffee intake, stratifying with gene polymorphisms, e.g., those in adenosine A 2A receptor (ADORA2A) and cytochrome P450 (CYP) 1A2, and daily caffeine consumption (≤90 mg/day and >90 mg/day). Overall, caffeine intake independently increased BP and calculation speed (p-values < 0.05), irrespective of the polymorphisms. In stratified analysis, a statistical significance within the caffeinated group was observed for the change in systolic BP in the stratum of CYP1A2 polymorphism with daily caffeine consumption ≤90 mg/day: change in systolic BP in the CYP1A2 rs762551 CC group (mean ± SD = 11.8 ± 5.9) was higher than that in the AA/CA group (4.1 ± 5.5). Gene polymorphisms may limitedly modify the effect of caffeine intake on hemodynamic parameters in combination with habitual caffeine consumption.",
author = "Tatsuya Yoshihara and Masayoshi Zaitsu and Fumie Shiraishi and Hisatomi Arima and Fumi Takahashi-Yanaga and masaki arioka and Shunichi Kajioka and Toshiyuki Sasaguri",
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T1 - Influence of genetic polymorphisms and habitual caffeine intake on the changes in blood pressure, pulse rate, and calculation speed after caffeine intake

T2 - A prospective, double blind, randomized trial in healthy volunteers

AU - Yoshihara, Tatsuya

AU - Zaitsu, Masayoshi

AU - Shiraishi, Fumie

AU - Arima, Hisatomi

AU - Takahashi-Yanaga, Fumi

AU - arioka, masaki

AU - Kajioka, Shunichi

AU - Sasaguri, Toshiyuki

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