Influence of intake of skin milk from cows immunized with intestinal bacterial antigens on onset of renal disease in (NZB x NZW)F1 mice fed ad libitum or restricted in energy intake

S. Murosaki, Y. Yoshikai, C. Kubo, A. Ishida, G. Matsuzaki, T. Sato, K. Endo, K. Nomoto

    研究成果: Contribution to journalArticle査読

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    Autoimmune disease-prone (NZB x NZW)F1 (B/W) female mice are a model of human lupus erythematosus. Immune milk, obtained from cows immunized with various intestinal bacterial antigens, was given to B/W mice as a component of diets beginning at 8 wk of age. Diets were fed ad libitum or restricted to 60% of ad libitum energy intake. Controls were fed commercial skim milk. In B/W mice fed ad libitum, the titers of anti-single-stranded DNA antibodies were significantly lower in immune milk-fed mice at 4 and 6 mo of age. Onset of proteinuria was delayed and life span was significantly prolonged by immune milk feeding. Surface phenotypes of the T cells and levels of the responsiveness of lymphocytes to mitogens were not changed by immune milk feeding. The B/W mice restricted to 60% of ad libitum energy intake, which preserved immune responsiveness, had not developed proteinuria by 14 mo of age, irrespective of immune milk feeding or control milk feeding. However, at 10 mo of age, the level of plasma antibodies against intestinal bacteria was significantly higher in energy-restricted mice fed control milk than in those fed immune milk or in mice fed ad libitum.

    本文言語英語
    ページ(範囲)1860-1868
    ページ数9
    ジャーナルJournal of Nutrition
    121
    11
    DOI
    出版ステータス出版済み - 1 1 1991

    All Science Journal Classification (ASJC) codes

    • Medicine (miscellaneous)
    • Nutrition and Dietetics

    フィンガープリント 「Influence of intake of skin milk from cows immunized with intestinal bacterial antigens on onset of renal disease in (NZB x NZW)F<sub>1</sub> mice fed ad libitum or restricted in energy intake」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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