Influence of light at night on melatonin suppression in children

Shigekazu Higuchi, Yuki Nagafuchi, Sang Il Lee, Tetsuo Harada

研究成果: Contribution to journalArticle査読

64 被引用数 (Scopus)

抄録

Context: The sensitivity of melatonin to light suppression is expected to be higher in children because children have large pupilsandpure crystal lenses. However, melatonin suppression by light in children remains unclear. Copyright

Objective: We investigated whether light-induced melatonin suppression in children is larger than that in adults.

Methods: Thirty-three healthy primary school children(meanage, 9.2±1.5 y)and29 healthy adults (meanage, 41.6±4.7 y) participated intwoexperiments. In the first experiment, salivary melatonin concentrations in 13 children and 13 adults were measured at night under a dim light (<30 lux) and a moderately bright light (580 lux) in an experimental facility. Pupil diameters were also measured under dim light and bright light. In the second experiment, melatonin concentrations in 20 children and 16 adults were measured under dim light in the experimental facility and under room light at home (illuminance, 140.0 ± 82.7 lux).

Results: In experiment 1, the melatonin concentration was significantly decreased by exposure to moderately bright light in both adults and children. Melatonin suppression was significantly larger in children (88.2%; n = 5) than in adults (46.3%; n = 6; P < .01), although the data for some participants were excluded because melatonin concentrations had not yet risen. In experiment 2, melatonin secretion was significantly suppressed by room light at home in children (n = 15; P < .05) but not in adults (n = 11).

Conclusion: We found that the percentage of melatonin suppression by light in children was almost twice that in adults, suggesting that melatonin is more sensitive to light in children than in adults at night.

本文言語英語
ページ(範囲)3298-3303
ページ数6
ジャーナルJournal of Clinical Endocrinology and Metabolism
99
9
DOI
出版ステータス出版済み - 9 1 2014

All Science Journal Classification (ASJC) codes

  • 内分泌学、糖尿病および代謝内科学
  • 生化学
  • 内分泌学
  • 臨床生化学
  • 生化学、医学

フィンガープリント

「Influence of light at night on melatonin suppression in children」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル