Objective: To examine the influence of medical history in parents or siblings on the development of systemic lupus erythematosus (SLE) among Japanese females. Methods: 160 female SLE patients and 660 female volunteers were studied in a case-control study. Unconditional logistic regression was used to compute OR and 95% CI, with adjustment for smoking, drinking, age and region. Results: The present study demonstrated that the risk of SLE was positively associated with family histories (i.e., medical histories in parents or siblings) of SLE (OR = 5.38, 95%CI = 1.43-20.20), rheumatoid arthritis (OR = 2.54, 95%CI = 1.08-5.96), collagen diseases (OR = 3.48, 95%CI = 1.87-6.48) and autoimmune diseases (OR = 5.25, 95%CI = 1.64-16.83). Conclusion: The result of the present study implies that common genetic and potential environmental factors among family members may lead to SLE, rheumatoid arthritis, and autoimmune diseases.
|ジャーナル||International Medical Journal|
|出版物ステータス||出版済み - 1 1 2016|
All Science Journal Classification (ASJC) codes