Influence of the bacterial phenotypes on the clinical manifestations in Klebsiella pneumoniae bacteremia patients: A retrospective cohort study

Atsushi Togawa, Hiromi Toh, Kyoko Onozawa, Michinobu Yoshimura, Chiemi Tokushige, Nobuyuki Shimono, Tohru Takata, Kazuo Tamura

研究成果: ジャーナルへの寄稿学術誌査読

14 被引用数 (Scopus)

抄録

Ninety-four episodes of Klebsiella pneumoniae bloodstream infection were identified at a university hospital in Japan. After excluding extended-spectrum beta lactamase-producing strains, 83 blood isolates from these patients were assayed in terms of their bacterial phenotypes such as the mucoid and hypermucoviscosity phenotypes. Bacterial phenotypes were correlated with the patients' clinical manifestations. The hypermucoviscosity phenotype was significantly associated with septic shock at the onset of infections (odds ratio, 15.92; 95% confidence interval, 1.27-468.12), but was not associated with liver abscess formation. Mortality was determined by the presence of septic shock. RmpA gene was associated with the induction of the hypermucoviscosity phenotype. These results reveal unique roles of bacterial phenotypes on the patient's clinical condition in K. pneumoniae bacteremia.

本文言語英語
ページ(範囲)531-537
ページ数7
ジャーナルJournal of Infection and Chemotherapy
21
7
DOI
出版ステータス出版済み - 12月 5 2015

!!!All Science Journal Classification (ASJC) codes

  • 微生物学(医療)
  • 薬理学(医学)
  • 感染症

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