Influence of the difference in refractive index on the interface of an object and the surroundings in near-infrared fluorescence tomography

Maho Takematsu; Masakazu Umezawa; Toshihiro Sera; Yuichi Kitagawa; Hiroyuki Kurahashi; Shuta Yamada; Kyohei Okubo; Masao Kamimura; Hideo Yokota; Kohei Soga

doi:10.1364/AO.445357

Influence of the difference in refractive index on the interface of an object and the surroundings in near-infrared fluorescence tomography

Maho Takematsu, Masakazu Umezawa, Toshihiro Sera, Yuichi Kitagawa, Hiroyuki Kurahashi, Shuta Yamada, Kyohei Okubo, Masao Kamimura, Hideo Yokota, Kohei Soga

生体工学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

2 被引用数 (Scopus)

抄録

The refraction of fluorescence from the inside of a sample at the surface results in fluctuations in fluorescence computed tomography (CT). We evaluated the influence of the difference in refractive index (RI) between the sample body and the surroundings on fluorescence CT results. The brightest fluorescent point is away from the correct point on the tomograms owing to the refraction. The speculated position is determined as the exact point if the RI ratio ranges between 0.97 and 1.03 by immersing the body in an RI matching liquid. The results can help in experimental settings of fluorescence CT for acquiring three-dimensional positional information.

本文言語	英語
ページ（範囲）	638-644
ページ数	7
ジャーナル	Applied Optics
巻	61
号	2
DOI	https://doi.org/10.1364/AO.445357
出版ステータス	出版済み - 1月 10 2022

!!!All Science Journal Classification (ASJC) codes

原子分子物理学および光学
工学（その他）
電子工学および電気工学

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10.1364/AO.445357

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引用スタイル

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abstract = "The refraction of fluorescence from the inside of a sample at the surface results in fluctuations in fluorescence computed tomography (CT). We evaluated the influence of the difference in refractive index (RI) between the sample body and the surroundings on fluorescence CT results. The brightest fluorescent point is away from the correct point on the tomograms owing to the refraction. The speculated position is determined as the exact point if the RI ratio ranges between 0.97 and 1.03 by immersing the body in an RI matching liquid. The results can help in experimental settings of fluorescence CT for acquiring three-dimensional positional information.",

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T1 - Influence of the difference in refractive index on the interface of an object and the surroundings in near-infrared fluorescence tomography

AU - Takematsu, Maho

AU - Umezawa, Masakazu

AU - Sera, Toshihiro

AU - Kitagawa, Yuichi

AU - Kurahashi, Hiroyuki

AU - Yamada, Shuta

AU - Okubo, Kyohei

AU - Kamimura, Masao

AU - Yokota, Hideo

AU - Soga, Kohei

N1 - Funding Information: Funding. Japan Science and Technology Agency (COINS); Ministry of Education, Culture, Sports, Science and Technology (15H05950, 19H01179). Publisher Copyright: © 2022 Optica Publishing Group

PY - 2022/1/10

Y1 - 2022/1/10

N2 - The refraction of fluorescence from the inside of a sample at the surface results in fluctuations in fluorescence computed tomography (CT). We evaluated the influence of the difference in refractive index (RI) between the sample body and the surroundings on fluorescence CT results. The brightest fluorescent point is away from the correct point on the tomograms owing to the refraction. The speculated position is determined as the exact point if the RI ratio ranges between 0.97 and 1.03 by immersing the body in an RI matching liquid. The results can help in experimental settings of fluorescence CT for acquiring three-dimensional positional information.

AB - The refraction of fluorescence from the inside of a sample at the surface results in fluctuations in fluorescence computed tomography (CT). We evaluated the influence of the difference in refractive index (RI) between the sample body and the surroundings on fluorescence CT results. The brightest fluorescent point is away from the correct point on the tomograms owing to the refraction. The speculated position is determined as the exact point if the RI ratio ranges between 0.97 and 1.03 by immersing the body in an RI matching liquid. The results can help in experimental settings of fluorescence CT for acquiring three-dimensional positional information.

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