Influence of the wettability of different titanium surface topographies on initial cellular behavior

Tomoko Nishimura, Yoichiro Ogino, Yasunori Ayukawa, Kiyoshi Koyano

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

This study examined the influence of the time-dependent wettability of different surface topographies on initial cellular behavior. Titanium disks with smooth topography (SM) and three kinds of rough topography (sandblasted (SA), microtopography (M) and nanotopography (N)) were prepared. Time-dependent changes in surface wettability were observed in all surfaces as shown in previous studies. On SM surfaces, hydrophobic alteration influenced cell spreading and the activity of RhoA (a small GTPase protein of the Rho family), while no alterations were observed on rough surfaces except for the number of adherent cells. Serum adsorption could recover these functional deteriorations by hydrophobic alteration. These findings suggest that surface topography is a more potent regulator in initial cellular behaviors such as cell spreading and RhoA activation than surface wettability.

本文言語英語
論文番号dmj/2017-334
ページ(範囲)650-658
ページ数9
ジャーナルdental materials journal
37
4
DOI
出版ステータス出版済み - 2018

All Science Journal Classification (ASJC) codes

  • セラミックおよび複合材料
  • 歯科学(全般)

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