Influence of transplanted dose of CD56 + cells on development of graft-versus-host disease in patients receiving G-CSF-mobilized peripheral blood progenitor cells from HLA-identical sibling donors

S. Yamasaki, H. Henzan, Y. Ohno, T. Yamanaka, T. Iino, Y. Itou, M. Kuroiwa, M. Maeda, N. Kawano, N. Kinukawa, T. Miyamoto, K. Nagafuji, K. Shimoda, S. Inaba, S. Hayashi, S. Taniguchi, T. Shibuya, H. Gondo, T. Otsuka, M. Harada

研究成果: Contribution to journalArticle査読

36 被引用数 (Scopus)

抄録

We investigated effects of variations in the cellular composition of G-CSF-mobilized peripheral blood progenitor cell (G-PBPC) allografts on clinical outcomes of allogeneic PBPC transplantation. We retrospectively analyzed transplanted doses of various immunocompetent cells from 27 HLA-identical sibling donors in relation to engraftment, incidence of graft-versus-host disease (GVHD), and survival. Significant variability was documented in both absolute numbers and relative proportions of CD34+, CD2+, CD3+, CD4high+, CD4+25+, CD8high+, CD19+, CD56+, and CD56+16+ cells contained in these allografts. Stepwise Cox regression analysis revealed that the CD56+ cell dose was significantly inversely correlated with the incidence of GVHD. Thus, there was a significantly higher incidence of grade II acute GVHD in patients receiving a lower CD56+16+ cell dose (hazard ratio (HR) 0.0090; 95% confidence interval (CI), <0.00001-3.38; P=0.031), a higher incidence of chronic GVHD in those receiving allografts with a lower CD56+16+ to CD34+ ratio (HR <0.00001; 95% CI <0.00001-0.0007; P=0.0035), and a higher incidence of extensive chronic GVHD in those receiving allografts with a lower CD5 + to CD34+ ratio (HR <0.00001; 95% CI <0.00001-0.053; P=0.0083). These results suggest that CD56+ cells in G-PBPC allografts from HLA-identical sibling donors may play an important role in preventing the development of GVHD.

本文言語英語
ページ(範囲)505-510
ページ数6
ジャーナルBone Marrow Transplantation
32
5
DOI
出版ステータス出版済み - 9 2003

All Science Journal Classification (ASJC) codes

  • 血液学
  • 移植

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