Inhalable nanocomposite particles using amino acids with improved drug content and humidity resistance

Issei Takeuchi, Yumi Tetsuka, Teruki Nii, Masayuki Shinogase, Kimiko Makino

研究成果: ジャーナルへの寄稿学術誌査読

16 被引用数 (Scopus)

抄録

In this study, we prepared various rifampicin-loaded poly(DL-lactide-co-glycolide) nanoparticles by changing the volume and pH of the aqueous phase to improve the content of rifampicin in the nanoparticles. The rifampicin content in the nanoparticles prepared in the aqueous phase volume of 40 mL (pH 4) was 1.36 times higher than that in the nanoparticles prepared in the aqueous phase volume of 100 mL (pH 7). From the results of in vitro release tests in phosphate-buffered saline at 37 °C for 24 h, we found that by reducing the volume and pH of the aqueous phase, the cumulative release rate of rifampicin from nanoparticles was significantly decreased. Then, we prepared nanocomposite particles using arginine and leucine as diluents. The aerodynamic diameters of the nanocomposite particles were measured using a cascade impactor. We found that the nanocomposite particles prepared using a diluent with arginine to leucine ratio of 1: 20 had the highest fine particle fraction value (32.63 ± 1.49%) and the particles were suitable for pulmonary delivery of bioactive materials deep in the lungs.

本文言語英語
ページ(範囲)387-393
ページ数7
ジャーナルColloids and Surfaces A: Physicochemical and Engineering Aspects
529
DOI
出版ステータス出版済み - 9月 20 2017
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 表面および界面
  • 物理化学および理論化学
  • コロイド化学および表面化学

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