Inhalation airflow and ventilation efficiency in subject-specific human upper airways

Chang Xu, Nguyen Dang Khoa, Sung Jun Yoo, Xin Zheng, Shifei Shen, Kazuhide Ito

研究成果: ジャーナルへの寄稿学術誌査読

6 被引用数 (Scopus)


The present numerical study investigated the transportation time of the inhaled chemicals in three realistic human airway models by adopting a methodology from the field of the building ventilation. Two indexes including “scale of ventilation efficiency 3 (SVE3)” and “local purging flow rate (L-PFR)” were used to evaluate the respective arrival time and staying time under different inhalation flow rates. The general trend of the SVE3 was predicted as expected and the exceptions within the nasal cavities were attributed to the uneven allocation of the inhaled flow between the internal channels and the formation of the vortex circulation therein. The complicated situation of the L-PFR was also explained by the structure constrains. Moreover, the variation of the two indexes with the flow rate was sensitive to the inter-subjective differences but the distribution pattern was not changed significantly. By combining the SVE3 and L-PFR, it could help with assessing the potential effect of the inhaled chemicals on the human health for engineering applications to which the relative impacts are more interested than the absolute value. But for the precise evaluation regarding a specific chemical, comprehensive simulation is still necessary with the surface adsorption included under realistic respiration cycles.

ジャーナルRespiratory Physiology and Neurobiology
出版ステータス出版済み - 3月 2021

!!!All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 生理学
  • 呼吸器内科


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