Inhibition of adhesion molecules markedly ameliorates cytokine-induced sustained myocardial dysfunction in dogs in vivo

Hidetoshi Momii, Hiroaki Shimokawa, Jun Ichi Oyama, Xiao Shu Cheng, Ryo Nakamura, Kensuke Egashira, Hiroe Nakazawa, Akira Takeshita

研究成果: ジャーナルへの寄稿学術誌査読

10 被引用数 (Scopus)

抄録

Adhesion molecules are key molecules for inflammatory cardiovascular diseases and are known to be up-regulated by inflammatory cytokines. However, the role of adhesion molecules in the cytokine-induced myocardial dysfunction in vivo remains unclear. This role was examined in our novel canine model, in which chronic treatment of the heart with IL-1β-bound microspheres (MS), but not control MS, causes sustained myocardial dysfunction in vivo. The expression of P-selectin (mRNA and immunoreactivity) was more prominent in the IL-1β group than in the control group (treated with control MS alone) after MS injection. The extent of neutrophil infiltration and myocardial myeloperoxidase (MPO) activity were significantly increased in the IL-1β group (P < 0.01). Pre-treatment with SLeX-OS (a novel oligosaccharide analog of sialyl Lewis(X)) or PB1.3 (a monoclonal antibody to P-selectin) prevented the myocardial dysfunction and significantly suppressed the neutrophil infiltration and the increase in myocardial MPO activity induced by IL-1β (P < 0.01 each). These results indicate that adhesion molecules play an important role in the pathogenesis of the cytokine-induced sustained myocardial dysfunction in dogs in vivo.

本文言語英語
ページ(範囲)2637-2650
ページ数14
ジャーナルJournal of Molecular and Cellular Cardiology
30
12
DOI
出版ステータス出版済み - 12月 1998
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 循環器および心血管医学

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