Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum

Sri Fatmawati; Kuniyoshi Shimizu; Ryuichiro Kondo

doi:10.1055/s-0030-1249782

Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum

Sri Fatmawati, Kuniyoshi Shimizu, Ryuichiro Kondo

サスティナブル資源科学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

27 被引用数 (Scopus)

抄録

CHCl₃ extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ganoderic acid C2 and ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.

本文言語	英語
ページ（範囲）	1691-1693
ページ数	3
ジャーナル	Planta medica
巻	76
号	15
DOI	https://doi.org/10.1055/s-0030-1249782
出版ステータス	出版済み - 2010

!!!All Science Journal Classification (ASJC) codes

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

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abstract = "CHCl3 extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ganoderic acid C2 and ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.",

author = "Sri Fatmawati and Kuniyoshi Shimizu and Ryuichiro Kondo",

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AU - Shimizu, Kuniyoshi

AU - Kondo, Ryuichiro

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N2 - CHCl3 extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ganoderic acid C2 and ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.

AB - CHCl3 extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ganoderic acid C2 and ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.

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JO - Planta Medica

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Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum

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!!!All Science Journal Classification (ASJC) codes

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