Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose

Yoshiko Miura, Chouga You, Reiko Ohnishi

研究成果: Contribution to journalArticle査読

16 被引用数 (Scopus)

抄録

A glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils from the amyloid β peptide (1-42) (Aβ), as evaluated by thioflavin T assay and atomic force microscopy. Glycopolymers carrying sugar alcohols also changed the aggregation properties of Aβ, and the inhibitory effect depended on the type of sugar and alkyl side chain. Neutralization activity was confirmed by in vitro assay using HeLa cells. The glycopolymer carrying trehalose strongly inhibited amyloid formation and neutralized cytotoxicity.

本文言語英語
論文番号024407
ジャーナルScience and Technology of Advanced Materials
9
2
DOI
出版ステータス出版済み - 4 1 2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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