Inhibition of alzheimer amyloid aggregation with sulfate glycopolymers

Yoshiko Miura, Kiyofumi Yamamoto, Kikuko Yasuda, Yoshihiro Nishida, Kazukiyo Kobayashi

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

1 被引用数 (Scopus)

抄録

Glycopolymers carrying sulfate saccharides were found to suppress the formation of amyloid fibrils by amyloid beta peptides, as evaluated by fluorescence assay of thioflavin T and AFM. CD spectra showed that the conformation of amyloid beta peptides was changed from beta peptides depended on the glycopolymer additives, and that the glycopolymer additives reduced the β-sheet contents. Neutralization activity was confirmed by in vitro assay with HeLa cells. The sulfate group and the appropriate sugar contents were essential for the inhibitory effect.

本文言語英語
ホスト出版物のタイトルCIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering
出版社Trans Tech Publications Ltd
ページ166-169
ページ数4
ISBN(印刷版)9783908158141
DOI
出版ステータス出版済み - 2008
外部発表はい
イベント3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering, CIMTEC 2008 - Acireale, Sicily, イタリア
継続期間: 6 8 20086 13 2008

出版物シリーズ

名前CIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering
57

その他

その他3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering, CIMTEC 2008
Countryイタリア
CityAcireale, Sicily
Period6/8/086/13/08

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomedical Engineering
  • Mechanics of Materials
  • Materials Science(all)

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