Inhibition of food passage by omeprazole in the chicken

Remedios T. Mabayo, Mitsuhiro Furuse, Jun ichi Okumura

研究成果: ジャーナルへの寄稿学術誌査読

9 被引用数 (Scopus)

抄録

The effect of omeprazole, a proton pump inhibitor, on the forward passage of the crop contents of chicks receiving 20% medium chain or long chain triacylglycerol was studied. Medium chain triacylglycerol significantly delayed the crop emptying of chicks compared with long chain triacylglycerol. Omeprazole also significantly inhibited passage from the crop of the long chain triacylglycerol meal. Application of omeprazole induces achlorhydria and consequently hypergastrinemia but chicken gastrin lower than 100 nmol/kg did not delay crop emptying. The addition of hydrochloric acid (HCl) to the diet reversed the action of omeprazole on the crop emptying of chicks. We conclude, then, that omeprazole delayed the crop emptying in chicks as a consequence of inhibition of acid secretion, although the mediator is not gastrin.

本文言語英語
ページ(範囲)161-165
ページ数5
ジャーナルEuropean Journal of Pharmacology
273
1-2
DOI
出版ステータス出版済み - 1月 24 1995
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 薬理学

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