Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells

Tomomi Ikegawa, Fumihiko Ushigome, Noriko Koyabu, Satoshi Morimoto, Yukihiro Shoyama, Mikihiko Naito, Takashi Tsuruo, Hisakazu Ohtani, Yasufumi Sawada

研究成果: ジャーナルへの寄稿記事

90 引用 (Scopus)

抄録

We investigated the effects of the ethyl acetate extract of grapefruit juice (GFJ), that of orange juice (OJ) and their components on the uptake of [3H]vincristine into adriamycin-resistant human myelogenous leukemia cells. Its uptake was increased by the extracts of GFJ and OJ up to 7- and 3-fold, respectively, as well as verapamil and cyclosporin A. OJ components, i.e. 3,3',4',5,6,7,8-heptamethoxyflavone, nobiletin and tangeretin, also increased the uptake of [3H]vincristine in a concentration-dependent manner. Although GFJ components, dihydroxybergamottin and bergamottin, significantly increased the uptake, their potencies were considerably weaker than those of OJ components. These data suggest that OJ components inhibit P-gp-mediated efflux of [3H]vincristine, resulting in the intracellular accumulation of chemotherapeutic drugs. These components may become candidates of multi-drug resistance reversing agents in cancer chemotherapy. Copyright (C) 2000 Elsevier Science Ireland Ltd.

元の言語英語
ページ(範囲)21-28
ページ数8
ジャーナルCancer Letters
160
発行部数1
DOI
出版物ステータス出版済み - 11 10 2000

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Myeloid Leukemia
K562 Cells
P-Glycoprotein
Doxorubicin
Citrus paradisi
Vincristine
Multiple Drug Resistance
Verapamil
Antineoplastic Agents
Cyclosporine
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells. / Ikegawa, Tomomi; Ushigome, Fumihiko; Koyabu, Noriko; Morimoto, Satoshi; Shoyama, Yukihiro; Naito, Mikihiko; Tsuruo, Takashi; Ohtani, Hisakazu; Sawada, Yasufumi.

:: Cancer Letters, 巻 160, 番号 1, 10.11.2000, p. 21-28.

研究成果: ジャーナルへの寄稿記事

Ikegawa, Tomomi ; Ushigome, Fumihiko ; Koyabu, Noriko ; Morimoto, Satoshi ; Shoyama, Yukihiro ; Naito, Mikihiko ; Tsuruo, Takashi ; Ohtani, Hisakazu ; Sawada, Yasufumi. / Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells. :: Cancer Letters. 2000 ; 巻 160, 番号 1. pp. 21-28.
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AU - Ohtani, Hisakazu

AU - Sawada, Yasufumi

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