Inhibition of porphobilinogen synthase activity by 4,5-dioxovalerate

Yuzo Shioi, Michio Doi, Tsutomu Sasa

研究成果: ジャーナルへの寄稿記事

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抜粋

The effect of 4,5-dioxovaleric acid on the activity of porphobilinogen (PBG) synthase (formerly 5-aminolevulinic acid dehydratase, EC 4.2.1.24) of the porphyrin synthetic pathway was studied with the enzyme purified from Chlorella regularis. 4,5-Dioxovaleric acid, a metabolite of 5-aminolevulinic acid, competitively inhibited PBG synthase with a Ki value of 1.4 mm. The concentration for the half inhibition of 4,5-dioxovaleric acid (7 mm) was slightly lower than that for the known competitive inhibitor, levulinic acid (12 mm).

元の言語英語
ページ(範囲)379-382
ページ数4
ジャーナルPlant and Cell Physiology
26
発行部数2
出版物ステータス出版済み - 3 1 1985

All Science Journal Classification (ASJC) codes

  • Physiology
  • Plant Science
  • Cell Biology

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