Inhibition of tumor growth and neovascularization by an anti-gastric ulcer agent, irsogladine

Mayumi Ono, Naoyuki Kawahara, Daisuke Goto, Yukihiro Wakabayashi, Shin Ushiro, Shigeo Yoshida, Hiroto Izumi, Michihiko Kuwano, Yasufumi Sato

研究成果: ジャーナルへの寄稿記事

68 引用 (Scopus)

抄録

Irsogladine used clinically as an anti-gastric ulcer agent, at 10-6- 10-4 M, inhibited cell proliferation and tubular morphogenesis of vascular endothelial cells, but the proliferation of human epidermoid cancer or glioma cells was not inhibited by this drug, even at 10-4 M. In vivo studies demonstrated that p.o. administration of irsogladine significantly inhibited tumor growth of human glioma cells in mice, and histological analysis showed a dramatic decrease of the neovascularization in the tumors. In mice transplanted with chambers containing human glioma cells or hepatic cancer cells, irsogladine also inhibited angiogenesis. These in vivo and in vitro assays demonstrate that irsogladine may be a unique and potent inhibitor of tumor angiogenesis.

元の言語英語
ページ(範囲)1512-1516
ページ数5
ジャーナルCancer Research
56
発行部数7
出版物ステータス出版済み - 4 1 1996

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irsogladine
Anti-Ulcer Agents
Gastrointestinal Agents
Stomach Ulcer
Glioma
Growth
Neoplasms
Cell Proliferation
Angiogenesis Inhibitors
Liver Neoplasms
Morphogenesis
Hepatocytes
Endothelial Cells

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Ono, M., Kawahara, N., Goto, D., Wakabayashi, Y., Ushiro, S., Yoshida, S., ... Sato, Y. (1996). Inhibition of tumor growth and neovascularization by an anti-gastric ulcer agent, irsogladine. Cancer Research, 56(7), 1512-1516.

Inhibition of tumor growth and neovascularization by an anti-gastric ulcer agent, irsogladine. / Ono, Mayumi; Kawahara, Naoyuki; Goto, Daisuke; Wakabayashi, Yukihiro; Ushiro, Shin; Yoshida, Shigeo; Izumi, Hiroto; Kuwano, Michihiko; Sato, Yasufumi.

:: Cancer Research, 巻 56, 番号 7, 01.04.1996, p. 1512-1516.

研究成果: ジャーナルへの寄稿記事

Ono, M, Kawahara, N, Goto, D, Wakabayashi, Y, Ushiro, S, Yoshida, S, Izumi, H, Kuwano, M & Sato, Y 1996, 'Inhibition of tumor growth and neovascularization by an anti-gastric ulcer agent, irsogladine', Cancer Research, 巻. 56, 番号 7, pp. 1512-1516.
Ono M, Kawahara N, Goto D, Wakabayashi Y, Ushiro S, Yoshida S その他. Inhibition of tumor growth and neovascularization by an anti-gastric ulcer agent, irsogladine. Cancer Research. 1996 4 1;56(7):1512-1516.
Ono, Mayumi ; Kawahara, Naoyuki ; Goto, Daisuke ; Wakabayashi, Yukihiro ; Ushiro, Shin ; Yoshida, Shigeo ; Izumi, Hiroto ; Kuwano, Michihiko ; Sato, Yasufumi. / Inhibition of tumor growth and neovascularization by an anti-gastric ulcer agent, irsogladine. :: Cancer Research. 1996 ; 巻 56, 番号 7. pp. 1512-1516.
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abstract = "Irsogladine used clinically as an anti-gastric ulcer agent, at 10-6- 10-4 M, inhibited cell proliferation and tubular morphogenesis of vascular endothelial cells, but the proliferation of human epidermoid cancer or glioma cells was not inhibited by this drug, even at 10-4 M. In vivo studies demonstrated that p.o. administration of irsogladine significantly inhibited tumor growth of human glioma cells in mice, and histological analysis showed a dramatic decrease of the neovascularization in the tumors. In mice transplanted with chambers containing human glioma cells or hepatic cancer cells, irsogladine also inhibited angiogenesis. These in vivo and in vitro assays demonstrate that irsogladine may be a unique and potent inhibitor of tumor angiogenesis.",
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AU - Goto, Daisuke

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AU - Ushiro, Shin

AU - Yoshida, Shigeo

AU - Izumi, Hiroto

AU - Kuwano, Michihiko

AU - Sato, Yasufumi

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