抄録
Several flavonoids, stilbenes and related 4-substituted resorcinols, obtained from Artocarpus incisus and other plants or synthesized, were tested for their inhibitory activity against tyrosinase. The structure-activity relationships suggested that specific natural or synthesized compounds having the 4-substituted resorcinol skeleton have potent tyrosinase inhibitory ability. Kinetic studies have indicated that specific compounds having the 4- substituted resorcinol skeleton exhibit competitive inhibition of the oxidation of DL-β-(3,4-dihydroxyphenyl)alanine (DL-DOPA) by mushroom tyrosinase. These findings could lead to the design and discovery of new tyrosinase inhibitors.
本文言語 | 英語 |
---|---|
ページ(範囲) | 11-15 |
ページ数 | 5 |
ジャーナル | Planta medica |
巻 | 66 |
号 | 1 |
DOI | |
出版ステータス | 出版済み - 2 26 2000 |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry