Inhibitors of ATP release inhibit vesicular nucleotide transporter

Yuri Kato, Hiroshi Omote, Takaaki Miyaji

研究成果: ジャーナルへの寄稿学術誌査読

16 被引用数 (Scopus)

抄録

Vesicular nucleotide transporter (VNUT) is responsible for vesicular ATP storage in ATP-secreting cells. In the present study, we examined the effects on VNUT-mediated transport of ATP release inhibitors such as ATP-binding cassette (ABC) proteins, hemichannels, maxi anion channels and P2X7 receptor. The ATP transport activity of proteoliposomes containing purified human VNUT was blocked by glibenclamide, carbenoxolone, 18 á-glycyrrhetinic acid, flufenamic acid, arachidonic acid and A438079 without the formation of Äø (positive inside) as a driving force being affected. Thus, inhibitors of ATP release may inhibit VNUT and subsequent ATP release, since the previous works proved that inhibitors of ATP release blocked VNUT-mediated ATP release at the cell level.

本文言語英語
ページ(範囲)1688-1691
ページ数4
ジャーナルBiological and Pharmaceutical Bulletin
36
11
DOI
出版ステータス出版済み - 11月 2013
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬科学

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