TY - JOUR
T1 - Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells
AU - Tangke Arung, Enos
AU - Matsubara, Eri
AU - Wijaya Kusuma, Irawan
AU - Sukaton, Edi
AU - Shimizu, Kuniyoshi
AU - Kondo, Ryuichiro
N1 - Funding Information:
This research supported by Japan Society for the Promotion of Science (JSPS) for Postdoctoral Fellow of Foreign Researchers.
PY - 2011/3
Y1 - 2011/3
N2 - In the course to find a new whitening agent, we evaluated the methanol extract from bud of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. Eugenol and eugenol acetate were isolated as the active compounds and showed melanin inhibition of 60% and 40% in B16 melanoma cell with less cytotoxicity at the concentration of 100 and 200μg/mL, respectively. Furthermore, an essential oil prepared from the bud of clove, which contain eugenol and eugenol acetate as dominant components, showed melanin inhibition of 50% and 80% in B16 melanoma cells at the concentration of 100 and 200 μg/mL, respectively.
AB - In the course to find a new whitening agent, we evaluated the methanol extract from bud of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. Eugenol and eugenol acetate were isolated as the active compounds and showed melanin inhibition of 60% and 40% in B16 melanoma cell with less cytotoxicity at the concentration of 100 and 200μg/mL, respectively. Furthermore, an essential oil prepared from the bud of clove, which contain eugenol and eugenol acetate as dominant components, showed melanin inhibition of 50% and 80% in B16 melanoma cells at the concentration of 100 and 200 μg/mL, respectively.
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U2 - 10.1016/j.fitote.2010.09.008
DO - 10.1016/j.fitote.2010.09.008
M3 - Article
C2 - 20858534
AN - SCOPUS:79952361583
SN - 0367-326X
VL - 82
SP - 198
EP - 202
JO - Fitoterapia
JF - Fitoterapia
IS - 2
ER -