Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells

Enos Tangke Arung, Eri Matsubara, Irawan Wijaya Kusuma, Edi Sukaton, Kuniyoshi Shimizu, Ryuichiro Kondo

研究成果: ジャーナルへの寄稿記事

39 引用 (Scopus)

抄録

In the course to find a new whitening agent, we evaluated the methanol extract from bud of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. Eugenol and eugenol acetate were isolated as the active compounds and showed melanin inhibition of 60% and 40% in B16 melanoma cell with less cytotoxicity at the concentration of 100 and 200μg/mL, respectively. Furthermore, an essential oil prepared from the bud of clove, which contain eugenol and eugenol acetate as dominant components, showed melanin inhibition of 50% and 80% in B16 melanoma cells at the concentration of 100 and 200 μg/mL, respectively.

元の言語英語
ページ(範囲)198-202
ページ数5
ジャーナルFitoterapia
82
発行部数2
DOI
出版物ステータス出版済み - 1 1 2011

Fingerprint

Syzygium
Eugenol
Experimental Melanomas
Melanins
Acetates
Bleaching Agents
Volatile Oils
Methanol

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

これを引用

Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. / Tangke Arung, Enos; Matsubara, Eri; Wijaya Kusuma, Irawan; Sukaton, Edi; Shimizu, Kuniyoshi; Kondo, Ryuichiro.

:: Fitoterapia, 巻 82, 番号 2, 01.01.2011, p. 198-202.

研究成果: ジャーナルへの寄稿記事

Tangke Arung, Enos ; Matsubara, Eri ; Wijaya Kusuma, Irawan ; Sukaton, Edi ; Shimizu, Kuniyoshi ; Kondo, Ryuichiro. / Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. :: Fitoterapia. 2011 ; 巻 82, 番号 2. pp. 198-202.
@article{e6ca5591446247ac885addd623d69cdb,
title = "Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells",
abstract = "In the course to find a new whitening agent, we evaluated the methanol extract from bud of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. Eugenol and eugenol acetate were isolated as the active compounds and showed melanin inhibition of 60{\%} and 40{\%} in B16 melanoma cell with less cytotoxicity at the concentration of 100 and 200μg/mL, respectively. Furthermore, an essential oil prepared from the bud of clove, which contain eugenol and eugenol acetate as dominant components, showed melanin inhibition of 50{\%} and 80{\%} in B16 melanoma cells at the concentration of 100 and 200 μg/mL, respectively.",
author = "{Tangke Arung}, Enos and Eri Matsubara and {Wijaya Kusuma}, Irawan and Edi Sukaton and Kuniyoshi Shimizu and Ryuichiro Kondo",
year = "2011",
month = "1",
day = "1",
doi = "10.1016/j.fitote.2010.09.008",
language = "English",
volume = "82",
pages = "198--202",
journal = "Fitoterapia",
issn = "0367-326X",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells

AU - Tangke Arung, Enos

AU - Matsubara, Eri

AU - Wijaya Kusuma, Irawan

AU - Sukaton, Edi

AU - Shimizu, Kuniyoshi

AU - Kondo, Ryuichiro

PY - 2011/1/1

Y1 - 2011/1/1

N2 - In the course to find a new whitening agent, we evaluated the methanol extract from bud of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. Eugenol and eugenol acetate were isolated as the active compounds and showed melanin inhibition of 60% and 40% in B16 melanoma cell with less cytotoxicity at the concentration of 100 and 200μg/mL, respectively. Furthermore, an essential oil prepared from the bud of clove, which contain eugenol and eugenol acetate as dominant components, showed melanin inhibition of 50% and 80% in B16 melanoma cells at the concentration of 100 and 200 μg/mL, respectively.

AB - In the course to find a new whitening agent, we evaluated the methanol extract from bud of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. Eugenol and eugenol acetate were isolated as the active compounds and showed melanin inhibition of 60% and 40% in B16 melanoma cell with less cytotoxicity at the concentration of 100 and 200μg/mL, respectively. Furthermore, an essential oil prepared from the bud of clove, which contain eugenol and eugenol acetate as dominant components, showed melanin inhibition of 50% and 80% in B16 melanoma cells at the concentration of 100 and 200 μg/mL, respectively.

UR - http://www.scopus.com/inward/record.url?scp=79952361583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952361583&partnerID=8YFLogxK

U2 - 10.1016/j.fitote.2010.09.008

DO - 10.1016/j.fitote.2010.09.008

M3 - Article

C2 - 20858534

AN - SCOPUS:79952361583

VL - 82

SP - 198

EP - 202

JO - Fitoterapia

JF - Fitoterapia

SN - 0367-326X

IS - 2

ER -