Inhibitory effect of a marine microalgal polysaccharide on the telomerase activity in K562 cells

Kenichi Sogawa, Tomoki Sumida, Hiroyuki Hamakawa, Takahisa Yamada, Kozo Matsumoto, Masahiro Matsuda, Hironobu Oda, Hidenori Miyake, Seiki Tashiro, Koichi Okutani

研究成果: Contribution to journalArticle査読

13 被引用数 (Scopus)

抄録

An extracellular polysaccharide from marine microalga, dinoflagellate Gymnodinium sp. A3 (GA3), showed cytotoxicity to human myeloid leukemia K562 cells. We measured telomerase activity in K562 cells cultured with GA3 polysaccharide. 10.0 μg/ml of GA3 polysaccharide inhibited the telomerase activity in the cells completely. Also, we found a decrease in expression of the catalytic subunit of protein phosphatase (PP) type 1, PP1γ1, in K562 cells cultured with GA3 polysaccharide.

本文言語英語
ページ(範囲)259-265
ページ数7
ジャーナルResearch Communications in Molecular Pathology and Pharmacology
99
3
出版ステータス出版済み - 3 1 1998

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 薬理学

フィンガープリント

「Inhibitory effect of a marine microalgal polysaccharide on the telomerase activity in K562 cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル