Inhibitory effect of a marine microalgal polysaccharide on the telomerase activity in K562 cells

Kenichi Sogawa, Tomoki Sumida, Hiroyuki Hamakawa, Takahisa Yamada, Kozo Matsumoto, Masahiro Matsuda, Hironobu Oda, Hidenori Miyake, Seiki Tashiro, Koichi Okutani

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

抄録

An extracellular polysaccharide from marine microalga, dinoflagellate Gymnodinium sp. A3 (GA3), showed cytotoxicity to human myeloid leukemia K562 cells. We measured telomerase activity in K562 cells cultured with GA3 polysaccharide. 10.0 μg/ml of GA3 polysaccharide inhibited the telomerase activity in the cells completely. Also, we found a decrease in expression of the catalytic subunit of protein phosphatase (PP) type 1, PP1γ1, in K562 cells cultured with GA3 polysaccharide.

元の言語英語
ページ(範囲)259-265
ページ数7
ジャーナルResearch Communications in Molecular Pathology and Pharmacology
99
発行部数3
出版物ステータス出版済み - 3 1 1998

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K562 Cells
Telomerase
Polysaccharides
Dinoflagellida
Protein Phosphatase 1
Myeloid Leukemia

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

これを引用

Sogawa, K., Sumida, T., Hamakawa, H., Yamada, T., Matsumoto, K., Matsuda, M., ... Okutani, K. (1998). Inhibitory effect of a marine microalgal polysaccharide on the telomerase activity in K562 cells. Research Communications in Molecular Pathology and Pharmacology, 99(3), 259-265.

Inhibitory effect of a marine microalgal polysaccharide on the telomerase activity in K562 cells. / Sogawa, Kenichi; Sumida, Tomoki; Hamakawa, Hiroyuki; Yamada, Takahisa; Matsumoto, Kozo; Matsuda, Masahiro; Oda, Hironobu; Miyake, Hidenori; Tashiro, Seiki; Okutani, Koichi.

:: Research Communications in Molecular Pathology and Pharmacology, 巻 99, 番号 3, 01.03.1998, p. 259-265.

研究成果: ジャーナルへの寄稿記事

Sogawa, K, Sumida, T, Hamakawa, H, Yamada, T, Matsumoto, K, Matsuda, M, Oda, H, Miyake, H, Tashiro, S & Okutani, K 1998, 'Inhibitory effect of a marine microalgal polysaccharide on the telomerase activity in K562 cells', Research Communications in Molecular Pathology and Pharmacology, 巻. 99, 番号 3, pp. 259-265.
Sogawa, Kenichi ; Sumida, Tomoki ; Hamakawa, Hiroyuki ; Yamada, Takahisa ; Matsumoto, Kozo ; Matsuda, Masahiro ; Oda, Hironobu ; Miyake, Hidenori ; Tashiro, Seiki ; Okutani, Koichi. / Inhibitory effect of a marine microalgal polysaccharide on the telomerase activity in K562 cells. :: Research Communications in Molecular Pathology and Pharmacology. 1998 ; 巻 99, 番号 3. pp. 259-265.
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AU - Matsuda, Masahiro

AU - Oda, Hironobu

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