Inhibitory effect of butylated hydroxyanisole administration on pancreatic carcinogenesis in syrian hamsters initiated with N-nitrosobis(2-oxopropyl)amine

Kazuhiro Mizumoto, Shinichi Ito, Shunji Kitazawa, Masahiro Tsutsumi, Ayumi Denda, Yoichi Konishi

研究成果: ジャーナルへの寄稿学術誌査読

14 被引用数 (Scopus)

抄録

The modifying potential of butylated bydroxyanisole (BHA) administration on pancreatic carcinogenesis was evaluated in 70 female Syrian golden hamsters. Groups of animals received saline, 70 mg/kg body weight of N-nitrosobis(2-oxopropyl)-amine (BOP) or 70 mg/kg plus 20 mg/kg body weight of BOP followed by basal diet or diet containing 2% BHA from week 3. Although the body weights of hamsters receiving the 2% BHA supplement decreased, caloric restriction was not observed. All hamsters were killed at week 18 and histo-pathologically examined for lesion development. The incidences of pancreatic carcinomas in hamsters receiving 70 mg/kg plus 20 mg/kg body weight of carcinogen followed by 2% BHA was 7.1%, significantly lower than the 64.3% evident in hamsters given the same doses of BOP followed by basal diet. The total numbers of pancreatic lesions including carcinomas, atypical ductal hyperplasias and ductal hyperplasias and ductular proliferations in the liver were also significantly decreased in animals receiving BOP followed by 2% BHA. The results thus indicate that both pancreatic and cholangiocellular carcinogenesis initiated by BOP in Syrian hamsters can be inhibited by 2% BHA treatment for a relatively short experimental period.

本文言語英語
ページ(範囲)1491-1494
ページ数4
ジャーナルCarcinogenesis
10
8
DOI
出版ステータス出版済み - 8月 1989

!!!All Science Journal Classification (ASJC) codes

  • 癌研究

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