The effect of Cd2+ and Hg2+ on transcription of the ada gene was examined using an in, vitro system reconstituted with Ada protein and methylated DNA, together with their effect on methyltransferase activity of the Ada protein. Both Cd2+ and Hg2+ inhibited transcription of the ada gene over the doses which did not inhibit methyltransferse activity.
|ジャーナル||Biochemical and Biophysical Research Communications|
|出版ステータス||出版済み - 9 30 1991|
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology