Inhibitory effect of isoprenoid-substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis

Enos Tangke Arung, Kuniyoshi Shimizu, Ryuichiro Kondo

研究成果: ジャーナルへの寄稿記事

40 引用 (Scopus)

抄録

Isoprenoid-substituted flavonoids were isolated from the wood of Artocarpus heterophyllus by means of activity-guided fractionation. Artocarpin (1), cudraflavone C (2), 6-prenylapigenin (3), kuwanon C (4), norartocarpin (5) and albanin A (6) inhibited melanin biosynthesis in B16 melanoma cells without inhibiting tyrosinase. A structure-activity investigation indicated that the presence of the isoprenoid-substituted moiety enhanced the inhibitory activity on melanin production in B16 melanoma cells.

元の言語英語
ページ(範囲)847-850
ページ数4
ジャーナルPlanta Medica
72
発行部数9
DOI
出版物ステータス出版済み - 7 1 2006

Fingerprint

Artocarpus
Experimental Melanomas
Biosynthesis
Melanins
Terpenes
Flavonoids
Monophenol Monooxygenase
Fractionation
Wood

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

これを引用

Inhibitory effect of isoprenoid-substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis. / Arung, Enos Tangke; Shimizu, Kuniyoshi; Kondo, Ryuichiro.

:: Planta Medica, 巻 72, 番号 9, 01.07.2006, p. 847-850.

研究成果: ジャーナルへの寄稿記事

@article{07fb84374d7b4b898537c10bd31233e6,
title = "Inhibitory effect of isoprenoid-substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis",
abstract = "Isoprenoid-substituted flavonoids were isolated from the wood of Artocarpus heterophyllus by means of activity-guided fractionation. Artocarpin (1), cudraflavone C (2), 6-prenylapigenin (3), kuwanon C (4), norartocarpin (5) and albanin A (6) inhibited melanin biosynthesis in B16 melanoma cells without inhibiting tyrosinase. A structure-activity investigation indicated that the presence of the isoprenoid-substituted moiety enhanced the inhibitory activity on melanin production in B16 melanoma cells.",
author = "Arung, {Enos Tangke} and Kuniyoshi Shimizu and Ryuichiro Kondo",
year = "2006",
month = "7",
day = "1",
doi = "10.1055/s-2006-931606",
language = "English",
volume = "72",
pages = "847--850",
journal = "Planta Medica",
issn = "0032-0943",
publisher = "Georg Thieme Verlag",
number = "9",

}

TY - JOUR

T1 - Inhibitory effect of isoprenoid-substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis

AU - Arung, Enos Tangke

AU - Shimizu, Kuniyoshi

AU - Kondo, Ryuichiro

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Isoprenoid-substituted flavonoids were isolated from the wood of Artocarpus heterophyllus by means of activity-guided fractionation. Artocarpin (1), cudraflavone C (2), 6-prenylapigenin (3), kuwanon C (4), norartocarpin (5) and albanin A (6) inhibited melanin biosynthesis in B16 melanoma cells without inhibiting tyrosinase. A structure-activity investigation indicated that the presence of the isoprenoid-substituted moiety enhanced the inhibitory activity on melanin production in B16 melanoma cells.

AB - Isoprenoid-substituted flavonoids were isolated from the wood of Artocarpus heterophyllus by means of activity-guided fractionation. Artocarpin (1), cudraflavone C (2), 6-prenylapigenin (3), kuwanon C (4), norartocarpin (5) and albanin A (6) inhibited melanin biosynthesis in B16 melanoma cells without inhibiting tyrosinase. A structure-activity investigation indicated that the presence of the isoprenoid-substituted moiety enhanced the inhibitory activity on melanin production in B16 melanoma cells.

UR - http://www.scopus.com/inward/record.url?scp=33746958913&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746958913&partnerID=8YFLogxK

U2 - 10.1055/s-2006-931606

DO - 10.1055/s-2006-931606

M3 - Article

VL - 72

SP - 847

EP - 850

JO - Planta Medica

JF - Planta Medica

SN - 0032-0943

IS - 9

ER -